Koilocytes are enriched for alkaline-labile sites

Submitted: 23 February 2010
Accepted: 7 April 2010
Published: 13 October 2010
Abstract Views: 871
PDF: 509
HTML: 2274
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

This study investigated possible variations in the chromatin structure of koilocytes resulting from human papillomavirus (HPV) infection. Alkaline-labile sites (ALS) were detected with the DNA breakage detection–fluorescence in situ hybridization (DBD-FISH) technique using a whole human genome DNA probe obtained from individuals without koilocytosis. The variable levels of ALS present were measured quantitatively using image analysis after whole-genome DNA hybridization. A significant increase in the number of ALS was observed in koilocytes compared with normal cells. We demonstrated that the presence of ALS could be an indicator of chromatin change in koilocytes caused by HPV infection.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

E. I. Cortés-Gutiérrez, Instituto Mexicano del Seguro Social
División de Genética. Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social
M. I. Dávila-Rodríguez, Instituto Mexicano del Seguro Social
División de Genética. Centro de Investigación Biomédica del Noreste, Instituto Mexicano del Seguro Social
J. L. Fernández, Complejo Hospitalario Universitario Juan Canalejo
Sección de Genética y Unidad de Investigación, Hospital Teresa Herrera, Complejo Hospitalario, Universitario Juan Canalejo
C. López-Fernández, Universidad Autónoma de Madrid
Universidad Autónoma de Madrid
J. Gosálvez, Universidad Autónoma de Madrid
Universidad Autónoma de Madrid

How to Cite

Cortés-Gutiérrez, E. I., Dávila-Rodríguez, M. I., Fernández, J. L., López-Fernández, C., & Gosálvez, J. (2010). Koilocytes are enriched for alkaline-labile sites. European Journal of Histochemistry, 54(4), e32. https://doi.org/10.4081/ejh.2010.e32

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.