https://doi.org/10.4081/ejh.2011.e15

Discrete foci containing RNAse A are found in nucleoli of HeLa cells after aging in culture

Vol. 55 No. 2 (2011)
Submitted: 4 April 2011
Accepted: 11 April 2011
Published: 13 April 2011
electron microscopy, immunocytochemistry
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Authors

M. Costanzo
University of Pavia, Italy.
B. Cisterna
University of Pavia, Italy.
O. O. Zharskaya
Russian Academy of Sciences, Russian Federation.
O. V. Zatsepina
Russian Academy of Sciences, Russian Federation.
M. Biggiogera
marcobig@unipv.it
University of Pavia, Italy.
We have studied by means of ultrastructural immunocytochemistry the localization of RNase A in nuclei of HeLa cells in control conditions and following cell ageing in culture. We have found that roundish, electron dense foci, which contain a significant amount of RNAse A, can be detected within nucleoli of aged cells. These bodies also contain RNA and lack ribosomal S3 proteins, and may represent either simple storage sites or areas where RNA degradation takes place.

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Supporting Agencies

CNR-RAS Scientific collaborative project, Russian Foundation for Basic Research (grant 08-04-00854).
M. Costanzo, University of Pavia
Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia Animale
B. Cisterna, University of Pavia
Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia Animale
O. O. Zharskaya, Russian Academy of Sciences
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry,
O. V. Zatsepina, Russian Academy of Sciences
Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry,
M. Biggiogera, University of Pavia
Laboratorio di Biologia Cellulare e Neurobiologia, Dipartimento di Biologia Animale

How to Cite

Costanzo, M., Cisterna, B., Zharskaya, O. O., Zatsepina, O. V., & Biggiogera, M. (2011). Discrete foci containing RNAse A are found in nucleoli of HeLa cells after aging in culture. European Journal of Histochemistry, 55(2), e15. https://doi.org/10.4081/ejh.2011.e15

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