Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy

Submitted: 12 September 2011
Accepted: 17 October 2011
Published: 24 October 2011
Abstract Views: 1175
PDF: 643
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Ulcerative colitis (UC) is a form of inflammatory bowel disease (IBD) characterized by damage of large bowel mucosa and frequent extra-intestinal autoimmune comorbidities. The role played in IBD pathogenesis by molecular chaperones known to interact with components of the immune system involved in inflammation is unclear. We previously demonstrated that mucosal Hsp60 decreases in UC patients treated with conventional therapies (mesalazine, probiotics), suggesting that this chaperonin could be a reliable biomarker useful for monitoring response to treatment, and that it might play a role in pathogenesis. In the present work we investigated three other heat shock protein/molecular chaperones: Hsp10, Hsp70, and Hsp90. We found that the levels of these proteins are increased in UC patients at the time of diagnosis and decrease after therapy, supporting the notion that these proteins deserve attention in the study of the mechanisms that promote the development and maintenance of IBD, and as biomarkers of this disease (e.g., to monitor response to treatment at the histological level).

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Supporting Agencies

University of Palermo, Istituto Euro-Mediterraneo di Scienza e Tecnologia
G. Tomasello, Università di Palermo
Dipartimento di Discipline Chirurgiche ed Oncologiche
C. Sciumé, Università di Palermo
Dipartimento di Discipline Chirurgiche ed Oncologiche
F. Rappa, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
V. Rodolico, Università di Palermo
Dipartimento di Patologia Umana
M. Zerilli, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
A. Martorana, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
G. Cicero, Università di Palermo
Dipartimento di Oncologia
R. De Luca, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
P. Damiani, Università di Palermo
Dipartimento di Medicina Interna e delle Malattie Emergenti
F.M. Accardo, Università di Palermo
Dipartimento di Contabilità Nazionale ed Analisi dei Processi Sociali
F. Farina, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
G. Bonaventura, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
G. Modica, Università di Palermo
Dipartimento di Discipline Chirurgiche ed Oncologiche
G. Zummo, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche
E. Conway de Macario, University of Maryland at Baltimore - IMET, Baltimore, MD
Department of Microbiology and Immunology,  School of Medicine
A.J.L. Macario, University of Maryland at Baltimore - IMET, Baltimore, MD
Department of Microbiology and Immunology,  School of Medicine
F. Cappello, Università di Palermo
Dipartimento di Biomedicina Sperimentale e Neuroscienze Cliniche

How to Cite

Tomasello, G., Sciumé, C., Rappa, F., Rodolico, V., Zerilli, M., Martorana, A., … Cappello, F. (2011). Hsp10, Hsp70, and Hsp90 immunohistochemical levels change in ulcerative colitis after therapy. European Journal of Histochemistry, 55(4), e38. https://doi.org/10.4081/ejh.2011.e38

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