https://doi.org/10.4081/ejh.2014.2358

Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway

Vol. 58 No. 1 (2014)
Submitted: 19 December 2013
Accepted: 11 February 2014
Published: 11 March 2014
cell nucleus, cerebral cavernous malformations, KRIT1, transcription, electron microscopy, immunocytochemistry.
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Authors

S. Marzo
University of Pavia, Italy.
V. Galimberti
University of Pavia, Italy.
M. Biggiogera
marcobig@unipv.it
University of Pavia, Italy.
KRIT1 is an 84kDa protein that lacks any relevant catalytic domains, associated with the cerebral cavernous malformation disease. We have investigated by means of ultrastructural immunocytochemistry the nuclear distribution of KRIT1 in different cell lines, revealing its unexpected localization on actively transcribing nuclear domains such as the perichromatin fibrils and the nucleolar dense fibrillar component. These preliminary data indicate a still undescribed and unknown role for KRIT1 inside the nucleus.

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S. Marzo, University of Pavia
Dipartimento di Biologia e Biotecnologie "Lazzaro Spallanzani"
V. Galimberti, University of Pavia
Dipartimento di Biologia e Biotecnologie "Lazzaro Spallanzani"
M. Biggiogera, University of Pavia
Dipartimento di Biologia e Biotecnologie "Lazzaro Spallanzani"

How to Cite

Marzo, S., Galimberti, V., & Biggiogera, M. (2014). Unexpected distribution of KRIT1 inside the nucleus: new insight in a complex molecular pathway. European Journal of Histochemistry, 58(1). https://doi.org/10.4081/ejh.2014.2358

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