Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kölliker’s organ in vivo in early stage after birth in rats

Submitted: 29 July 2016
Accepted: 21 June 2017
Published: 7 August 2017
Abstract Views: 1195
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Kölliker’s organ is a temporary but indispensable structure in the development of the cochlea. Supporting cells (SCs) within it release adenosine 5'-triphosphate (ATP), which may play a crucial role in cochlear development before the onset of hearing. To reveal the apoptosis of Kölliker’s  organ in new-born rats, we studied the morphological changes and expression of apoptosis-related factors during early postnatal development. We found SCs in Kölliker’s s organ decreased in number and changed in appearance along the cochlea apex-to-base gradient, and the expression of caspase-3, caspase-8, caspase-9 and bcl-2 in Kölliker’s  organ of the cochlea fluctuated along the course of postnatal development, with an expression peak at postnatal day 3. This study demonstrates a time-dependent degeneration of Kölliker’s  organ during postnatal cochlea development, which might be triggered by endogenous factors.Â

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Supporting Agencies

National Natural Science Foundation of China, Shanghai Municipal Science and Technology Commission, Huawei Li, Fudan University.

How to Cite

Liu, J., Cai, L., He, Y., & Yang, J. (2017). Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kölliker’s organ in vivo in early stage after birth in rats. European Journal of Histochemistry, 61(3). https://doi.org/10.4081/ejh.2017.2706