Cover Image

High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling

G. Tossetta, C. Avellini, C. Licini, S.R. Giannubilo, M. Castellucci, D. Marzioni
  • G. Tossetta
    Polytechnic University of Marche, Department of Experimental and Clinical Medicine, Italy
  • C. Avellini
    Polytechnic University of Marche, Department of Experimental and Clinical Medicine, Italy
  • C. Licini
    Polytechnic University of Marche, Department of Experimental and Clinical Medicine, Italy
  • S.R. Giannubilo
    Polytechnic University of Marche, Department of Clinical Sciences, Italy
  • M. Castellucci
    Polytechnic University of Marche, Department of Experimental and Clinical Medicine, Italy
  • D. Marzioni
    Polytechnic University of Marche, Department of Experimental and Clinical Medicine, Italy | d.marzioni@univpm.it

Abstract

High temperature requirement A1 (HtrA1) is a secreted protease involved in placental development. Fibronectin (FN) is involved in important process such as wound healing, cell adhesion and spreading, growth, migration, and differentiation. The purpose of this study was to analyse the expression patterns of HtrA1 in relationship to FN and to the key growth zones of placenta such as mesenchymal villi as well as cell islands and cell columns. We demonstrated that FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation.

Keywords

Placenta; HtrA1; fibronectin; fibrinoid; mesenchymal villi.

Full Text

PDF
HTML
Submitted: 2016-09-13 12:40:49
Published: 2016-11-21 12:09:14
Search for citations in Google Scholar
Related articles: Google Scholar
Abstract views:
364

Views:
PDF
84
HTML
85

Article Metrics

Metrics Loading ...

Metrics powered by PLOS ALM


Copyright (c) 2016 Giovanni Tossetta, Chiara Avellini, Caterina Licini, Stefano Raffaele Giannubilo, Mario Castellucci, Daniela Marzioni

Creative Commons License
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
 
© PAGEPress 2008-2017     -     PAGEPress is a registered trademark property of PAGEPress srl, Italy.     -     VAT: IT02125780185