https://doi.org/10.4081/ejh.2010.e7

Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney

Vol. 54 No. 1 (2010)
Submitted: 12 January 2010
Accepted: 12 January 2010
Published: 8 February 2010
KCNQ1 K channel, Rana esculenta, frog kidney, immunohistochemistry
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Authors

S. Ćirović
University of Belgrade, .
J. Marković-Lipkovski
acal@matf.bg.ac.rs
University of Belgrade, .
J. Todorović
University of Belgrade, .
J. Nešović-Ostojić
University of Belgrade, .
M. Jović
Military Medical Academy, Belgrade, .
S. Ilić
Military Medical Academy, Belgrade, .
S. Tatić
University of Belgrade, .
D. Čemerikić
University of Belgrade, .
The aim of this study was to evaluate KCNQ1 K+ channel expression in the frog kidney of Rana esculenta. KCNQ1 K+ channel, also known as KvLQT1, is the pore forming a-subunit of the IKs K+ channel, a delayed rectifier voltage-gated K+ channel, which has an important role in water and salt transport in the kidney and gastrointestinal tract. The expression of KCNQ1 K+ channel along tubular epithelium differs from species to species. In the present study the expression of KCNQ1 K+ channel in the frog kidney has been demonstrated by immunohistochemistry. The presence of KCNQ1 K+ channel was demonstrated in the epithelial cells of distal convoluted tubule and collecting duct. However, the pattern of expression of KCNQ1 K+ channel differs between distal convoluted tubules and collecting duct. All epithelial cells of distal convoluted tubules revealed basolateral expression of KCNQ1 K+ channel. On the contrary, only the single cells of collecting duct, probably intercalated cells, showed diffuse cell surface staining with antibodies against KCNQ1 K+ channel. These findings suggest that KCNQ1 K+ channel has cell-specific roles in renal potassium ion transport.

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Supporting Agencies

Ministry of Science and Technological Development of the Republic of Serbia.
J. Marković-Lipkovski, University of Belgrade
Institute of Pathology, Faculty of Medicine

How to Cite

Ćirović, S., Marković-Lipkovski, J., Todorović, J., Nešović-Ostojić, J., Jović, M., Ilić, S., Tatić, S., & Čemerikić, D. (2010). Differential expression of KCNQ1 K+ channel in tubular cells of frog kidney. European Journal of Histochemistry, 54(1), e7. https://doi.org/10.4081/ejh.2010.e7

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