https://doi.org/10.4081/ejh.2024.3973
Mast cells in meningiomas
Submitted: 19 January 2024
Accepted: 19 March 2024
Published: 18 April 2024
Accepted: 19 March 2024
Abstract Views: 494
PDF: 196
HTML: 7
HTML: 7
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Meningioma represents the most frequent tumor of the central nervous system (CNS). Correlations between the presence of mast cells (MCs) and grade or other histological features of meningioma are still debated. Our study aimed to better understand the relationship between mast cells and meningiomas and to compare our results based on specific histological subtypes and novel 2021 CNS WHO grading system. We observed some differences as regards the number of MCs and meningioma grade. In low-grade (grade 1) meningiomas, MCs were observed in 7/22 cases, while they were consistently present in all eight high-grade cases (grade 2 and grade 3). Among the grade 1 meningiomas, we observed two “low-positive”, two “intermediate-positive”, and three “high-positive” cases. Among the group of high-grade meningiomas, the six cases grade 2 were considered as “low-positive”, while the two grade 3 cases showed a higher number of MCs and were included in the “intermediate-positive” group. Even though with no statistical significance, due to the low number of cases, our results seem to confirm a sort of relationship between meningioma grading and the number of MCs, as demonstrated by the higher percentage of high-grade meningiomas showing MCs infiltrates, compared to low-grade meningiomas.
Ostrom QT, Price M, Neff C, Cioffi G, Waite KA, Kruchko C, et al. CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2015-2019. Neuro Oncol 2022;24:v1-v95.
DOI: https://doi.org/10.1093/neuonc/noac202
Kemnitz, P, Spormann H, Heinrich P. Meningioma of lung: first report with light and electron microscopic findings. Ultrastruct Pathol 1982;3:359-65.
DOI: https://doi.org/10.3109/01913128209018558
Kershisnik M, Callender DL, Batsakis JG. Extracranial, extraspinal meningiomas of the head and neck. Ann Otol Rhinol Laryngol 1993;102:967-70.
DOI: https://doi.org/10.1177/000348949310201211
Perry A, Gutmann DH, Reifenberger G. Molecular pathogenesis of meningiomas. J Neurooncol 2004;70:183-202.
DOI: https://doi.org/10.1007/s11060-004-2749-0
World Health Organization. Female Genital Tumours. WHO Classification of Tumours Series. Available from: https://publications.iarc.fr/Book-And-Report-Series/Who-Classification-Of-Tumours/Female-Genital-Tumours-2020
Louis DN, Perry A, Wesseling P, Brat DJ, Cree IA, Figarella-Branger D, et al. The 2021 WHO classification of tumors of the central nervous system: a summary. Neuro Oncol 2021;23:1231-51.
DOI: https://doi.org/10.1093/neuonc/noab106
Hasselblatt M, Nolte KW, Paulus W. Angiomatous meningioma: A clinicopathologic study of 38 cases. Am J Surg Pathol 2004;28:390.
DOI: https://doi.org/10.1097/00000478-200403000-00013
Bitzer M, Nägele T, Geist-Barth B, Klose U, Grönewäller E, Morgalla M, et al. Role of hydrodynamic processes in the pathogenesis of peritumoral brain edema in meningiomas. J Neurosurg 2000;93:594-604.
DOI: https://doi.org/10.3171/jns.2000.93.4.0594
Bujan B, Mennel HD. Elevated numbers of mast cells in angiomatous meningioma. Clin Neuropathol 2015;34:54-6.
DOI: https://doi.org/10.5414/NP300779
Tirakotai W, Mennel HD, Celik I, Hellwig D, Bertalanffy H, Riegel, T. Secretory meningioma: immunohistochemical findings and evaluation of mast cell infiltration. Neurosurg Rev 2006;29:41-8.
DOI: https://doi.org/10.1007/s10143-005-0402-9
Polyzoidis S, Koletsa T, Panagiotidou S, Ashkan K, Theoharide T.C. Mast cells in meningiomas and brain inflammation. J Neuroinflammation 2015;12:170.
DOI: https://doi.org/10.1186/s12974-015-0388-3
Reszec J, Hermanowicz A, Kochanowicz J, Turek G, Mariak Z, Chyczewski L. Mast cells evaluation in meningioma of various grades. Folia Histochem Cytobiol 2012;50:542-6.
DOI: https://doi.org/10.5603/14744
Reszec J, Hermanowicz A, Rutkowski R, Bernaczyk P, Mariak Z, Chyczewski L. Evaluation of Mast cells and hypoxia inducible factor-1 expression in meningiomas of various grades in correlation with peritumoral brain edema. J Neurooncol 2013;115:119-25.
DOI: https://doi.org/10.1007/s11060-013-1208-1
Bø L, Mørk SJ, Nyland H. An immunohistochemical study of mononuclear cells in meningiomas. Neuropathol Appl Neurobiol 1992;18:548-58.
DOI: https://doi.org/10.1111/j.1365-2990.1992.tb00825.x
Ribatti D, Crivellato E. Mast cells, angiogenesis, and tumour growth. Biochim Biophys Acta 2012;1822:2-8.
DOI: https://doi.org/10.1016/j.bbadis.2010.11.010
Zhao J, Hou Y, Yin C, Hu J, Gao T, Huang X, et al. Upregulation of histamine receptor H1 promotes tumor progression and contributes to poor prognosis in hepatocellular carcinoma. Oncogene 2020;39:1724-38.
DOI: https://doi.org/10.1038/s41388-019-1093-y
Moradi A, Semnani V, Djam H, Tajodini A, Zali AR, Ghaemi K, et al. Pathodiagnostic parameters for meningioma grading. J Clin Neurosci 2008;15:1370-5.
DOI: https://doi.org/10.1016/j.jocn.2007.12.005
Haslund-Vinding J, Møller JR, Ziebell M, Vilhardt F, Mathiesen T. The role of systemic inflammatory cells in meningiomas. Neurosurg Rev 2022;45:1205-15.
DOI: https://doi.org/10.1007/s10143-021-01642-x
Ethics Approval
this study was approved by the Institutional Review Board at the Bari Policlinico Hospital, University of Bari “Aldo Moro”Supporting Agencies
European Union Seventh Framework ProgramHow to Cite
D’Amati, A., Tamma, R., Annese, T., Rizzi, A., & Ribatti, D. (2024). Mast cells in meningiomas. European Journal of Histochemistry, 68(2). https://doi.org/10.4081/ejh.2024.3973
Copyright (c) 2024 The Author(s)
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Claudia Frick, Hanna Luisa Martin, Johanna Bruder, Kerstin Lang, Heinz Breer, Topographic distribution pattern of morphologically different G cells in the murine antral mucosa , European Journal of Histochemistry: Vol. 61 No. 3 (2017)
- S. Nemolato, T. Cabras, M.U. Fanari, F. Cau, M. Fraschini, B. Manconi, I. Messana, M. Castagnola, G. Faa, Thymosin beta 4 expression in normal skin, colon mucosa and in tumor infiltrating mast cells , European Journal of Histochemistry: Vol. 54 No. 1 (2010)
- Tadashi Yasui, Kenya Miyata, Chie Nakatsuka, Azuma Tsukise, Hiroshi Gomi, Morphological and histochemical characterization of the secretory epithelium in the canine lacrimal gland , European Journal of Histochemistry: Vol. 65 No. 4 (2021)
- S. Huang, S. Guo, F. Guo, Q. Yang, X. Xiao, M. Murata, S. Ohnishi, S. Kawanishi, N. Ma, CD44v6 expression in human skin keratinocytes as a possible mechanism for carcinogenesis associated with chronic arsenic exposure , European Journal of Histochemistry: Vol. 57 No. 1 (2013)
- A. Porzionato, M. Rucinski, V. Macchi, G. Sarasin, L.K. Malendowicz, R. De Caro, ECRG4 expression in normal rat tissues: expression study and literature review , European Journal of Histochemistry: Vol. 59 No. 2 (2015)
- Alimu Keremu, Pazila Aila, Aikebaier Tusun , Maimaitiaili Abulikemu, Xiaoguang Zou, Extracellular vesicles from bone mesenchymal stem cells transport microRNA-206 into osteosarcoma cells and target NRSN2 to block the ERK1/2-Bcl-xL signaling pathway , European Journal of Histochemistry: Vol. 66 No. 3 (2022)
- F. Merigo, F. Boschi, C. Lasconi, D. Benati, A. Sbarbati, Molecules implicated in glucose homeostasis are differentially expressed in the trachea of lean and obese Zucker rats , European Journal of Histochemistry: Vol. 60 No. 1 (2016)
- A. Makowiecka, A. Simiczyjew, D. Nowak, A.J. Mazur, Varying effects of EGF, HGF and TGFβ on formation of invadopodia and invasiveness of melanoma cell lines of different origin , European Journal of Histochemistry: Vol. 60 No. 4 (2016)
- H.S. Lee, J.H. Chang, S.K. Ku, An immunohistochemical study of the pancreatic endocrine cells of the Korean golden frog, Rana plancyi chosenica , European Journal of Histochemistry: Vol. 56 No. 1 (2012)
- R.J. BuÅ‚dak, M. Skonieczna, Å. BuÅ‚dak, N. Matysiak, Å. MielaÅ„czyk, G. Wyrobiec, M. Kukla, M. Michalski, K. Å»wirska-Korczala, Changes in subcellular localization of visfatin in human colorectal HCT-116 carcinoma cell line after cytochalasin B treatment , European Journal of Histochemistry: Vol. 58 No. 3 (2014)
You may also start an advanced similarity search for this article.
Publication Facts
Metric
This article
Other articles
Peer reviewers
2
2.4
Reviewer profiles N/A
Author statements
Author statements
This article
Other articles
Data availability
N/A
16%
External funding
N/A
32%
Competing interests
N/A
11%
Metric
This journal
Other journals
Articles accepted
57%
33%
Days to publication
89
145
- Editor & editorial board
- profiles
- Academic society
- N/A
- Publisher
- PAGEPress Publications, Pavia, Italy
To learn about these publication facts, click 
PF is maintained by the Public Knowledge Project
