Original Papers
26 June 2009
Vol. 47 No. 1 (2003)
9
0
3
0
Smart Citations
9
0
3
0
Citing PublicationsSupportingMentioningContrasting
View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Nucleoli in large (giant) bi- and multinucleate cells after apoptosis-inducing photodynamic treatment

Authors

The present experimental study was undertaken to provide information on nucleolar changes accompanying the apoptotic process in large or giant binucleate and multinucleate cells (LBMNCs). Such cells were present in a small but constant percentage in cultures of HL-60 cells. The apoptotic process was induced by photodynamic treatment (PDT) by means of 5-aminolaevulinic acid (ALA) as the precursor of the photosensitizer protoporphyrin IX and irradiation with broad spectrum blue light (BL). Nucleolar changes in LBMNCs were characterized by marked reduction or disappearance of silver stained particles representing AgNORs in nucleoli including the large ones. In addition, PDT also significantly reduced the number of nucleoli regardless of their size. These changes apparently reflected the decrease or cessation of nucleolar biosynthetic activities and resembled those which were previously observed in naturally maturing bone marrow megakaryocytes (Janoutová et al., 2001).

Altmetrics

Downloads

Citations

How to Cite



Nucleoli in large (giant) bi- and multinucleate cells after apoptosis-inducing photodynamic treatment. (2009). European Journal of Histochemistry, 47(1), 39-44. https://doi.org/10.4081/805