Effect of a topical treatment in organotypic culture of human breast skin after exposure to gamma-rays

Published: 10 August 2009
Abstract Views: 526
PDF: 523
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

The early radiation of epidermal reactions can lead to healing of the lesion or radiation necrosis. There is no general agreement for either the prevention and/or treatment of radiation skin response, also as little is known about the immediate phases of this phenomenon. We investigated the early effects exerted by Healing and Wound Emulsion (HWE) on human skin response after ionizing radiation. Epidermal morphology, Heat Shock Protein (HSP) 70, and Transforming Growth Factor-b1 (TGF-b1) gene expression were investigated in organotypic human skin cultures undergoing a double dose of gamma-rays (2 Gy). HSP70 gene expression tended to be induced in the HWE group 6 hours after cream administration and was significantly up-regulated after 48 hours, when epidermal morphological alterations were evident. TGF- b1 seems not affected in cream treated samples. HWE may stimulate skin to mount an early defensive response against damage induced by gamma rays.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

How to Cite

Gagliano, N., Bedoni, M., Mantovani, G., Chiriva-Internati, M., Castelli, D., Torri, C., & Donetti, E. (2009). Effect of a topical treatment in organotypic culture of human breast skin after exposure to gamma-rays. European Journal of Histochemistry, 51(4), 283–290. https://doi.org/10.4081/1153