Effect of recombinant TRAIL in a murine co-culture system of osteoclastogenesis

Abstract

Although some experimental evidence has implicated the TRAIL/TRAIL-receptor system in the regulation of osteoclastogenesis, the only available studies performed so far have been performed on isolated pre-osteoclasts, induced to differentiate by the addition of recombinant RANKL and M-CSF. Using a more physiological co-culture system in the absence of exogenous cytokines, we have here demonstrated that recombinant TRAIL inhibits osteoclast formation, but only at relatively high concentrations (500 ng/mL).

Downloads

Download data is not yet available.
Published
2009-08-12
Section
Original Papers
Statistics
Abstract views: 181

PDF: 168
Share it

PlumX Metrics

PlumX Metrics provide insights into the ways people interact with individual pieces of research output (articles, conference proceedings, book chapters, and many more) in the online environment. Examples include, when research is mentioned in the news or is tweeted about. Collectively known as PlumX Metrics, these metrics are divided into five categories to help make sense of the huge amounts of data involved and to enable analysis by comparing like with like.

How to Cite
Nicolin, V., Narducci, P., & Celeghini, C. (2009). Effect of recombinant TRAIL in a murine co-culture system of osteoclastogenesis. European Journal of Histochemistry, 52(1), 75-78. https://doi.org/10.4081/1189

Most read articles by the same author(s)