Effect of recombinant TRAIL in a murine co-culture system of osteoclastogenesis

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V Nicolin *
P Narducci
C Celeghini
(*) Corresponding Author:
V Nicolin | support@pagepress.org


Although some experimental evidence has implicated the TRAIL/TRAIL-receptor system in the regulation of osteoclastogenesis, the only available studies performed so far have been performed on isolated pre-osteoclasts, induced to differentiate by the addition of recombinant RANKL and M-CSF. Using a more physiological co-culture system in the absence of exogenous cytokines, we have here demonstrated that recombinant TRAIL inhibits osteoclast formation, but only at relatively high concentrations (500 ng/mL).

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