https://doi.org/10.4081/ejh.2001.1620

Fluorescent RT in situ PCR detection of MRP1 mRNA in human HCV infected liver

Vol. 45 No. 1 (2001)
Submitted: 24 December 2009
Accepted: 24 December 2009
Published: 24 December 2009
Abstract Views: 507
PDF: 527
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Authors

L Pascolo
support@pagepress.org
PAGEPress Office, Pavia, Italy.
S Bogoni
A Spanò
E Demori
A Amoroso
S Crovella
Chronic hepatitis C is now a major cause of chronic liver disease, cirrhosis and hepatocellular carcinoma. Approximately 20% of cases of acute viral hepatitis are due to hepatitis C. Cirrhosis develops in more than 25% of patients with chronic infection and each year hepatocellular carcinoma occurs in 1-3% of patients with cirrhosis due to HCV (Hoofnagle 1999). Patients with hepatocellular carcinoma are characterized by nonresponsiveness to chemotherapeutic agents. A cause of refractivity to treatment has been ascribed to the overexpression of the Pgp (MDR) protein (Kim et al. 1999), and the additional involvement of multidrug resistance-associated proteins (MRPs) has been also hypothesized (Minemura et al. 1999).

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How to Cite

Pascolo, L., Bogoni, S., Spanò, A., Demori, E., Amoroso, A., & Crovella, S. (2009). Fluorescent RT in situ PCR detection of MRP1 mRNA in human HCV infected liver. European Journal of Histochemistry, 45(1), 105–8. https://doi.org/10.4081/ejh.2001.1620
Copyright (c) 2009 L Pascolo, S Bogoni, A Spanò, E Demori, A Amoroso, S Crovella Creative Commons License

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