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Engagement of the periesophageal ring during Holothuria polii response to erythrocyte injection

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In Holothuria polii, the periesophageal ring is an important organ supplying spherule cells after stimulation with foreign material. In animals injected with formalinized sheep erythrocytes, in fact, a depletion of spherule cells is observed in the periesophageal ring, whereas in the connective tissue, in the external epithelium and around the antigen- injected site, small, transparent cells can be visualized. It is supposed that the latter are stem cells of spherule cells.

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D’Ancona Lunetta, G., & Michelucci, M. (2009). Engagement of the periesophageal ring during Holothuria polii response to erythrocyte injection. European Journal of Histochemistry, 46(2), 185–94. https://doi.org/10.4081/1669