Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation

Submitted: 23 January 2010
Accepted: 23 January 2010
Published: 23 January 2010
Abstract Views: 658
PDF: 831
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The transcription factor p53 and the cytokine receptor FasL are two of the most famous regulators of cell life, and their alterations can cause a large number of pathologies, including cancer. In this review, we focused on how they can determine defective apoptosis, one of the causes of tumorigenesis and tumor progression. The importance of this knowledge lies in the new perspectives that gene therapy can offer to cure cancer.

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Cappello, F., Bellafiore, M., Palma, A., & Bucchieri, F. (2010). Defective apoptosis and tumorigenesis: role of p53 mutation and Fas/FasL system dysregulation. European Journal of Histochemistry, 46(3), 199–208. https://doi.org/10.4081/1680