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Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas

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Neuroblastoma is the most common extracranial solid malignant tumor observed during childhood. Although these tumors can sometimes regress spontaneously or respond well to treatment in infants, genetic alterations that influence apoptosis can, in some cases, confer resistance to chemotherapy or result in relapses and adversely affect prognosis for these patients. The aim of this study was to correlate immunohistochemical expression of the protein QSOX1 (quiescin sulfhydryl oxidase 1) in samples obtained from untreated neuroblastomas with the patients’ clinical and pathological prognostic factors and clinical course. Neuroblastoma samples (n=23) obtained from histology blocks were arrayed into tissue microarrays and analysed by immunohistochemistry. The cases were classified according to the following clinical and pathological prognostic factors: age at diagnosis greater or less than/equal to 18 months; location of the lesion at diagnosis (abdominal or extra-abdominal); presence or absence of bone-marrow infiltration; tumor differentiation (well or poorly differentiated); Shimada histopathologic classification (favourable or unfavourable); state of the tumor extracellular matrix (Schwannian-stroma rich or poor); amplification of the MYCN oncogene; and clinical course (dead or alive with or without relapses/residual lesions). Twelve of the cases were female, 9 children were over 18 months old, 9 cases presented with extra-abdominal tumors and 9 cases exhibited tumors with unfavourable histologies. Fifteen patients underwent bone-marrow biopsy, and 4 of these were positive for metastasis. Nine patients died. The higher immunohistochemical expression of QSOX1 was more common in well-differentiated samples (P=0.029), in stroma-rich samples (P=0.029) and in samples from patients with a high prevalence of relapses/residual disease. The functions of QSOX1 include extracellular matrix maturation and the induction of apoptosis. Therefore, QSOX1 may be involved in neuroblastoma differentiation and regression and may thus function as a biomarker for identifying risk groups for this neoplasm.

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Development of tandem antigen capture ELISAs measuring QSOX1 isoforms in plasma and serum. Free Radical Biology and Medicine, 210, 212.
10.1016/j.freeradbiomed.2023.11.018
Xiao-Fei Zhang, Ji Wang, Hu-Liang Jia, Wen-Wei Zhu, Lu Lu, Qing-Hai Ye, Peter J. Nelson, Yi Qin, Dong-Mei Gao, Hai-Jun Zhou, Lun-Xiu Qin (2019)
Core fucosylated glycan-dependent inhibitory effect of QSOX1-S on invasion and metastasis of hepatocellular carcinoma. Cell Death Discovery, 5(1),
10.1038/s41420-019-0164-8
Jin A. Baek, Phil Hyun Song, YoungHwii Ko, Mi Jin Gu (2018)
High expression of QSOX1 is associated with tumor invasiveness and high grades groups in prostate cancer. Pathology - Research and Practice, 214(7), 964.
10.1016/j.prp.2018.05.019
Xiaochuan LIU, Yuwei YANG, Ping JIANG, Xiaohui LI, Yanliang GE, Yang CAO, Zhihui ZHAO, Xibi FANG, Xianzhong YU (2018)
Effect of QSOX1 on cattle carcass traits as well as apoptosis and triglyceride production in bovine fetal fibroblasts and mammary epithelial cells. Journal of Veterinary Medical Science, 80(8), 1329.
10.1292/jvms.17-0705
Tao Jiang, Li Zheng, Xia Li, Jia Liu, Hu Song, Yixin Xu, Chenhua Dong, Lianyu Liu, Hongyu Wang, Shuai Wang, Renhao Wang, Jun Song (2021)
Quiescin Sulfhydryl Oxidase 2 Overexpression Predicts Poor Prognosis and Tumor Progression in Patients With Colorectal Cancer: A Study Based on Data Mining and Clinical Verification. Frontiers in Cell and Developmental Biology, 9,
10.3389/fcell.2021.678770
Nava Reznik, Deborah Fass (2022)
Disulfide bond formation and redox regulation in the Golgi apparatus. FEBS Letters, 596(22), 2859.
10.1002/1873-3468.14510

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How to Cite

Araújo, D., Nakao, L., Gozzo, P., Souza, C., Balderrama, V., Gugelmin, E., … de Noronha, L. (2014). Expression level of quiescin sulfhydryl oxidase 1 (QSOX1) in neuroblastomas. European Journal of Histochemistry, 58(1). https://doi.org/10.4081/ejh.2014.2228

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