https://doi.org/10.4081/ejh.2014.2249
Immunohistochemical localization of nerve fibers in the pseudocapsule of fibroids
Accepted: 17 March 2014
HTML: 1350
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The pseudocapsule surrounding fibroids consists of compressed myometrium  containing nerves and blood vessels that continue into adjacent myometrium. Oxytocin (OXT) is thought to affect wound healing after myomectomy. We determined the presence of OXT and protein gene product 9.5 (PGP9.5) immunoreactive nerve fibers in pseudocapsule compared to adjacent myometrium. Samples (N=106) of pseudocapsule and adjacent myometrium were collected from 57 women with uterine fibroids undergoing myomectomy, and stained with anti-OXT and PGP 9.5 antibodies to demonstrate the presence of nerve fibers. Nerve fibers in the pseudocapsule stained positively with OXT (89/106, 84.0%) and PGP 9.5 (94/106, 88.7%). The densities of nerve fibers staining with PGP 9.5 and OXT in the pseudocapsule were highest in the isthmus (23.68±22.45/mm2 and 43.35±40.74/mm2, respectively). There were no significant differences in the density of nerve fibers, stained with either OXT or PGP 9.5, between the pseudocapsule, and adjacent normal myometrium regardless of the fibroid location in the uterus (P>0.05). These results suggest that the pseudocapsule should avoid to be damaged during the myomectomy procedure.
Supporting Agencies
National Nature Science Foundation of China (81270672), Nature Science Foundation of Zhejiang Province (Y2110181 and Y2110128), Zhejiang Science major projects (2011C13028-1)How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- D. Kluchova, A. Bolekova, C. Heichel, A. J. Bron, I. Kozak, NADPH-diaphorase expression in the Meibomian glands of rat palpebra in postnatal development , European Journal of Histochemistry: Vol. 54 No. 4 (2010)
- K.R. Torres-da-Silva, A.V. da Silva, N.O. Barioni, G.W.L. Tessarin, J.A. de Oliveira, E. Ervolino, J.A.C. Horta-Junior, C.A. Casatti, Neurochemistry study of spinal cord in non-human primate (Sapajus spp.) , European Journal of Histochemistry: Vol. 60 No. 3 (2016)
- T. Kocsis, J. Baán, G. Müller, L. Mendler, L. Dux, A. Keller-Pintér, Skeletal muscle cellularity and glycogen distribution in the hypermuscular Compact mice , European Journal of Histochemistry: Vol. 58 No. 3 (2014)
- W. Romero-Fernandez, D.O. Borroto-Escuela, V. Vargas-Barroso, M. Narváez, M. Di Palma, L.F. Agnati, J. Larriva Sahd, K. Fuxe, Dopamine D1 and D2 receptor immunoreactivities in the arcuate-median eminence complex and their link to the tubero-infundibular dopamine neurons , European Journal of Histochemistry: Vol. 58 No. 3 (2014)
- L. Ragionieri, M. Botti, F. Gazza, C. Sorteni, R. Chiocchetti, P. Clavenzani, L. Bo, R. Panu, Localization of peripheral autonomic neurons innervating the boar urinary bladder trigone and neurochemical features of the sympathetic component , European Journal of Histochemistry: Vol. 57 No. 2 (2013)
- M. Hinken, S. Halwachs, C. Kneuer, W. Honscha, Subcellular localization and distribution of the reduced folate carrier in normal rat tissues , European Journal of Histochemistry: Vol. 55 No. 1 (2011)
- G.A. Caprara, S. Perni, C. Morabito, M.A. Mariggiò, S. Guarnieri, Specific association of growth-associated protein 43 with calcium release units in skeletal muscles of lower vertebrates , European Journal of Histochemistry: Vol. 58 No. 4 (2014)
- G. Natale, E. Pompili, F. Biagioni, S. Paparelli, P. Lenzi, F. Fornai, Histochemical approaches to assess cell-to-cell transmission of misfolded proteins in neurodegenerative diseases , European Journal of Histochemistry: Vol. 57 No. 1 (2013)
- H. Xu, X. Zhang, H. Wang, Y. Zhang, Y. Shi, X. Zhang, Continuous cyclic mechanical tension increases ank expression in endplate chondrocytes through the TGF-β1 and p38 pathway , European Journal of Histochemistry: Vol. 57 No. 3 (2013)
- Mariko Kawai, Yu-Ki Ohmori, Mai Nishino, Masayo Yoshida, Kaori Tabata, Do-Saku Hirota, Ayako Ryu-Mon, Hiromitsu Yamamoto, Junya Sonobe, Yo-Hei Kataoka, Noriko Shiotsu, Mika Ikegame, Hiroki Maruyama, Toshio Yamamoto, Kazuhisa Bessho, Kiyoshi Ohura, Determination of cell fate in skeletal muscle following BMP gene transfer by in vivo electroporation , European Journal of Histochemistry: Vol. 61 No. 2 (2017)
You may also start an advanced similarity search for this article.
