Immunolocalization of NGF and its receptors in ovarian surface epithelium of the wild ground squirrel during the breeding and nonbreeding seasons

  • L. Bao | baolihong@imun.edu.cn Inner Mongolia University for Nationalities, China.
  • Q. Li Beijing Forestry University, China.
  • Y. Liu Beijing Forestry University, China.
  • B. Li Beijing Forestry University, China.
  • X. Sheng Beijing Forestry University, China.
  • Y. Han Beijing Forestry University, China.
  • Q. Weng Beijing Forestry University, China.

Abstract

The ovarian surface epithelium (OSE) plays an important role in normal ovarian physiology. During each reproductive cycle, the OSE takes part in the cyclical ovulatory ruptures and repair. The aim of this study was to investigate the immunolocalization of nerve growth factor (NGF) and its receptors, tyrosine kinase A (TrkA) and p75, in the OSE cells of the wild ground squirrels during the breeding and nonbreeding seasons. There were marked variations in ovarian weight and size between the breeding and the nonbreeding seasons. Histologically, cuboidal cells and squamous cells were identified in the OSE of both seasons. Yet, stronger immunostaining of NGF, TrkA and p75 were observed in cuboidal cells and squamous cells in the breeding season as compared to the nonbreeding season. In addition, plasma gonadotropin concentrations were higher in the breeding season than in the nonbreeding season, suggesting that the expression patterns of NGF, TrkA and p75 in the OSE were correlated with changes in plasma gonadotropins. These findings suggested that NGF and its receptor TrkA and p75 may be involved in the regulation of seasonal changes in the OSE of wild ground squirrel.in the OSE of wild ground squirrel.

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Author Biographies

L. Bao, Inner Mongolia University for Nationalities
Institute of Public Health
Q. Li, Beijing Forestry University
Laboratory of Animal Physiology, College of Biological Sciences and Technology
Y. Liu, Beijing Forestry University
Laboratory of Animal Physiology, College of Biological Sciences and Technology
B. Li, Beijing Forestry University
Laboratory of Animal Physiology, College of Biological Sciences and Technology
X. Sheng, Beijing Forestry University
Laboratory of Animal Physiology, College of Biological Sciences and Technology
Y. Han, Beijing Forestry University
Laboratory of Animal Physiology, College of Biological Sciences and Technology
Q. Weng, Beijing Forestry University
Laboratory of Animal Physiology, College of Biological Sciences and Technology
Published
2014-05-09
Section
Original Papers
Supporting Agencies
This study was partially supported by a Grant-in-Aid from Changjiang Scholars and Innovative Research Team in Universities (IRT0607) from China.
Keywords:
Ground squirrel, NGF, OSE, p75, TrkA.
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How to Cite
Bao, L., Li, Q., Liu, Y., Li, B., Sheng, X., Han, Y., & Weng, Q. (2014). Immunolocalization of NGF and its receptors in ovarian surface epithelium of the wild ground squirrel during the breeding and nonbreeding seasons. European Journal of Histochemistry, 58(2). https://doi.org/10.4081/ejh.2014.2363