Histochemistry as a unique approach for investigating normal and osteoarthritic cartilage

  • G. Musumeci | g.musumeci@unict.it University of Catania, Italy.
  • P. Castrogiovanni University of Catania, Italy.
  • V. Mazzone University of Catania, Italy.
  • M.A. Szychlinska University of Catania, Italy.
  • S. Castorina University of Catania, Italy.
  • C. Loreto University of Catania, Italy.


In this review article, we describe benefits and disadvantages of the established histochemical methods for studying articular cartilage tissue under normal, pathological and experimental conditions. We illustrate the current knowledge on cartilage tissue based on histological and immunohistochemical aspects, and in conclusion we provide a short overview on the degeneration of cartilage, such as osteoarthritis. Adult articular cartilage has low capacity to repair itself, and thus even minor injuries may lead to progressive damage and osteoarthritic joint degeneration, resulting in significant pain and disability. Numerous efforts have been made to implement the knowledge in the study of cartilage in the last years, and histochemistry proved to be an especially powerful tool to this aim.


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Author Biography

G. Musumeci, University of Catania
Department of Bio-Medical Sciences, Human Anatomy Section, School of Medicine.
Reviews - 60th Anniversary EJH
Supporting Agencies
Department of Bio-Medical Sciences, University of Catania.
Cartilage, knee arthroplasty, osteoarthritis, histology, histochemistry, immunohistochemistry.
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How to Cite
Musumeci, G., Castrogiovanni, P., Mazzone, V., Szychlinska, M., Castorina, S., & Loreto, C. (2014). Histochemistry as a unique approach for investigating normal and osteoarthritic cartilage. European Journal of Histochemistry, 58(2). https://doi.org/10.4081/ejh.2014.2371

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