Brain morphological defects in prolidase deficient mice: first report

Submitted: 14 April 2014
Accepted: 8 July 2014
Published: 17 September 2014
Abstract Views: 1384
PDF: 536
HTML: 324
Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.

Authors

Prolidase gene (PEPD) encodes prolidase enzyme, which is responsible for hydrolysis of dipeptides containing proline or hydroxyproline at their C-terminal end. Mutations in PEPD gene cause, in human, prolidase deficiency (PD), a rare autosomal recessive disorder. PD patients show reduced or absent prolidase activity and a broad spectrum of phenotypic traits including various degrees of mental retardation. This is the first report correlating PD and brain damages using as a model system prolidase deficient mice, the so called dark-like (dal) mutant mice. We focused our attention on dal postnatal brain development, revealing a panel of different morphological defects in the cerebral and cerebellar cortices, such as undulations of the cerebral cortex, cell rarefaction, defects in cerebellar cortex lobulation, and blood vessels overgrowth. These anomalies might be ascribed to altered angiogenic process and loss of pial basement membrane integrity. Further studies will be directed to find a correlation between neuroarchitecture alterations and functional consequences.

Dimensions

Altmetric

PlumX Metrics

Downloads

Download data is not yet available.

Citations

V. Insolia, University of Pavia
Department of Biology and Biotechnology "Lazzaro Spallanzani"
V.M. Piccolini, University of Pavia - Institute of Molecular Genetics of CNR

Department of Biology and Biotechnology "Lazzaro Spallanzani" 

Histochemistry and Cytometry Section

How to Cite

Insolia, V., & Piccolini, V. (2014). Brain morphological defects in prolidase deficient mice: first report. European Journal of Histochemistry, 58(3). https://doi.org/10.4081/ejh.2014.2417

Similar Articles

1 2 3 4 5 6 7 8 9 10 > >> 

You may also start an advanced similarity search for this article.