https://doi.org/10.4081/ejh.2015.2451
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Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?

Authors

Y.F. Costa
University of São Paulo, Brazil.
K.C. Tjioe
University of São Paulo, Brazil.
S. Nonogaki
Adolfo Lutz Institute, Brazil.
F.A. Soares
A.C. Camargo Cancer Hospital, Brazil.
J.R. Pereira Lauris
University of São Paulo, Brazil.
D. Tostes Oliveira
denisetostes@usp.br
University of São Paulo, Brazil.
The association between podoplanin and ezrin in the process of odontogenic tumors invasion has been suggested, but was not studied yet. Our purpose was to investigate the relationship between podoplanin and ezrin expressions in the odontogenic epithelium of ameloblastomas. Forty-seven ameloblastomas were analyzed by immunohistochemistry using anti-podoplanin and anti-ezrin antibodies. The expressions of both proteins were evaluated using a score method and the comparison and association between these proteins were verified, respectively, by Wilcoxon Signed-Rank test and by Spearman’s rank correlation coefficient, using a statistical significance level of 0.05. The majority of tumors (87.2%) exhibited strong membranous expression of podoplanin in the peripheral cells. Cytoplasmic expression of ezrin in the peripheral cells of ameloblastomas was stronger than its membranous expression. No statistically significant correlation was observed between podoplanin and ezrin. However, there was statistically significant difference between membranous podoplanin and membranous ezrin expressions, between cytoplasmic podoplanin and membranous ezrin expressions, and between cytoplasmic podoplanin and cytoplasmic ezrin expressions. There was no statistical difference between membranous podoplanin and cytoplasmic ezrin expressions. These results suggest a synergistic role of both proteins in the process of invasion of ameloblastomas.

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Citations

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Giulia G. Malaguez, Etiene A. Munhoz, Elena R.C. Rivero, Pantelis V. Rados, Marcia G. Oliveira (2020)
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Developing odontoma (ameloblastic fibro-odontoma) of the mandible: Report of a case with radiological, histopathological and immunohistochemical studies. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 36(4), 648.
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Mario Alberto Alarcón-Sánchez, Getsemani Luna-Bonilla, Selenne Romero-Servin, Artak Heboyan (2024)
Podoplanin immunoexpression in odontogenic lesions: a systematic review, meta-analysis, and integrated bioinformatic analysis. Diagnostic Pathology, 19(1),
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Supporting Agencies

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (grants #2012/08278-5 and #2012/13411-6)
Y.F. Costa, University of São Paulo
Department of Stomatology, Area of Pathology, Bauru School of Dentistry
K.C. Tjioe, University of São Paulo
Department of Stomatology, Area of Pathology, Bauru School of Dentistry
S. Nonogaki, Adolfo Lutz Institute
Pathology Division
F.A. Soares, A.C. Camargo Cancer Hospital
Department of Pathology
J.R. Pereira Lauris, University of São Paulo
Department of Community Dentistry, Bauru School of Dentistry
D. Tostes Oliveira, University of São Paulo
Department of Stomatology, Area of Pathology, Bauru School of Dentistry

How to Cite

Costa, Y., Tjioe, K., Nonogaki, S., Soares, F., Pereira Lauris, J., & Tostes Oliveira, D. (2015). Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?. European Journal of Histochemistry, 59(1). https://doi.org/10.4081/ejh.2015.2451

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