0
0
0
0
Smart Citations
0
0
0
0
Citing PublicationsSupportingMentioningContrasting
View Citations

See how this article has been cited at scite.ai

scite shows how a scientific paper has been cited by providing the context of the citation, a classification describing whether it supports, mentions, or contrasts the cited claim, and a label indicating in which section the citation was made.

Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?

Authors

The association between podoplanin and ezrin in the process of odontogenic tumors invasion has been suggested, but was not studied yet. Our purpose was to investigate the relationship between podoplanin and ezrin expressions in the odontogenic epithelium of ameloblastomas. Forty-seven ameloblastomas were analyzed by immunohistochemistry using anti-podoplanin and anti-ezrin antibodies. The expressions of both proteins were evaluated using a score method and the comparison and association between these proteins were verified, respectively, by Wilcoxon Signed-Rank test and by Spearman’s rank correlation coefficient, using a statistical significance level of 0.05. The majority of tumors (87.2%) exhibited strong membranous expression of podoplanin in the peripheral cells. Cytoplasmic expression of ezrin in the peripheral cells of ameloblastomas was stronger than its membranous expression. No statistically significant correlation was observed between podoplanin and ezrin. However, there was statistically significant difference between membranous podoplanin and membranous ezrin expressions, between cytoplasmic podoplanin and membranous ezrin expressions, and between cytoplasmic podoplanin and cytoplasmic ezrin expressions. There was no statistical difference between membranous podoplanin and cytoplasmic ezrin expressions. These results suggest a synergistic role of both proteins in the process of invasion of ameloblastomas.

Downloads

Publication Facts

Metric
This article
Other articles
Peer reviewers 
2
2.4

Reviewer profiles  N/A

Author statements

Author statements
This article
Other articles
Data availability 
N/A
16%
External funding 
N/A
32%
Competing interests 
Yes
11%
Metric
This journal
Other journals
Articles accepted 
58%
33%
Days to publication 
165
145

Indexed in

Editor & editorial board
profiles
Academic society 
N/A

PFL

1 2 3 4 5
Not useful Very useful

Citations

Crossref
12
Scopus
0
Mojgan Alaeddini, Nosratollah Eshghyar, Shahroo Etemad‐Moghadam (2017)
Expression of podoplanin and TGF‐beta in glandular odontogenic cyst and its comparison with developmental and inflammatory odontogenic cystic lesions. Journal of Oral Pathology & Medicine, 46(1), 76.
10.1111/jop.12475
Paula Nascimento Antonio, Natália Galvão Garcia, Agnes Assao, José Roberto Pereira Lauris, Fernando Augusto Soares, Denise Tostes Oliveira (2018)
Immunoexpression of proteins involved in cytoskeleton remodeling in benign odontogenic lesions. Archives of Oral Biology, 87, 151.
10.1016/j.archoralbio.2017.12.017
Shahroo Etemad‐Moghadam, Mojgan Alaeddini (2018)
Is podoplanin expression associated with transforming growth factor‐β signaling in odontogenic cysts and tumors?. Journal of Oral Pathology & Medicine, 47(5), 519.
10.1111/jop.12710
Giulia G. Malaguez, Etiene A. Munhoz, Elena R.C. Rivero, Pantelis V. Rados, Marcia G. Oliveira (2020)
Podoplanin Expression in Odontogenic Keratocysts Associated or not Associated With Nevoid Basal Cell Carcinoma Syndrome. Applied Immunohistochemistry & Molecular Morphology, 28(7), 513.
10.1097/PAI.0000000000000785
Alexandre Simões Garcia, Agnes Assao, André Lopes Carvalho, Fernando Augusto Soares, Luiz Paulo Kowalski, Denise Tostes Oliveira (2019)
The stem cell markers expression CD44v6 and podoplanin in lip cancer: clinical significance. Virchows Archiv, 474(6), 745.
10.1007/s00428-019-02539-3
Saya Imaoka, Ayuko Moriyama, Hiroshi Shiratsuchi, Takaaki Tamagawa, Masatake Asano (2024)
Developing odontoma (ameloblastic fibro-odontoma) of the mandible: Report of a case with radiological, histopathological and immunohistochemical studies. Journal of Oral and Maxillofacial Surgery, Medicine, and Pathology, 36(4), 648.
10.1016/j.ajoms.2023.11.004
Mario Alberto Alarcón-Sánchez, Getsemani Luna-Bonilla, Selenne Romero-Servin, Artak Heboyan (2024)
Podoplanin immunoexpression in odontogenic lesions: a systematic review, meta-analysis, and integrated bioinformatic analysis. Diagnostic Pathology, 19(1),
10.1186/s13000-024-01540-y
Byeong-Oh Hwang, Se-Young Park, Eunae Sandra Cho, Xianglan Zhang, Sun Kyoung Lee, Hyung-Joon Ahn, Kyung-Soo Chun, Won-Yoon Chung, Na-Young Song (2021)
Platelet CLEC2-Podoplanin Axis as a Promising Target for Oral Cancer Treatment. Frontiers in Immunology, 12,
10.3389/fimmu.2021.807600
Sai Madhav Gabbiti, Ch. Gnyana Deepika, V. Swathi, Chandrashekar Poosarla, Vatsalya Kommalapati, Kiran Kumar Kattappagari (2024)
Immunohistochemical Analysis of Podoplanin expression across histopathological variants of Ameloblastomas: A Retrospective Study. Journal of Indian Dental Association,
10.33882/jida.15.37037
Naznin KHADIZA, Tomoka HASEGAWA, Tomoya NAGAI, Tomomaya YAMAMOTO, Yukina MIYAMOTO- TAKASAKI, Hiromi HONGO, Miki ABE, Mai HARAGUCHI, Tsuneyuki YAMAMOTO, YIMIN, Zixuan QIU, Muneteru SASAKI, Shinichiro KUROSHIMA, Hayato OHSHIMA, Paulo Henrique Luiz de FREITAS, Minqi LI, Yasutaka YAWAKA, Norio AMIZUKA (2019)
Immunolocalization of podoplanin/E11/gp38, CD44, and endomucin in the odontoblastic cell layer of murine tooth germs. Biomedical Research, 40(4), 133.
10.2220/biomedres.40.133
MohammadSina ArabSheibani, Safoura Seifi, Jahanshah Salehinejad, Ali Bijani (2020)
Expression of CD34, VEGFR3 and eosinophil density in selected odontogenic tumors- a pilot study. Journal of Oral Biology and Craniofacial Research, 10(1), 367.
10.1016/j.jobcr.2019.09.003
Tomoya Nagai, Tomoka Hasegawa, Yimin, Tomomaya Yamamoto, Hiromi Hongo, Miki Abe, Taiji Yoshida, Ayako Yokoyama, Paulo Henrique Luiz de Freitas, Minqi Li, Atsuro Yokoyama, Norio Amizuka (2021)
Immunocytochemical assessment of cell differentiation of podoplanin-positive osteoblasts into osteocytes in murine bone. Histochemistry and Cell Biology, 155(3), 369.
10.1007/s00418-020-01937-y

Supporting Agencies

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) (grants #2012/08278-5 and #2012/13411-6)
Y.F. Costa, University of São Paulo
Department of Stomatology, Area of Pathology, Bauru School of Dentistry
K.C. Tjioe, University of São Paulo
Department of Stomatology, Area of Pathology, Bauru School of Dentistry
S. Nonogaki, Adolfo Lutz Institute
Pathology Division
F.A. Soares, A.C. Camargo Cancer Hospital
Department of Pathology
J.R. Pereira Lauris, University of São Paulo
Department of Community Dentistry, Bauru School of Dentistry
D. Tostes Oliveira, University of São Paulo
Department of Stomatology, Area of Pathology, Bauru School of Dentistry

How to Cite

Costa, Y., Tjioe, K., Nonogaki, S., Soares, F., Pereira Lauris, J., & Tostes Oliveira, D. (2015). Are podoplanin and ezrin involved in the invasion process of the ameloblastomas?. European Journal of Histochemistry, 59(1). https://doi.org/10.4081/ejh.2015.2451

Similar Articles

<< < 3 4 5 6 7 8 9 10 11 12 > >> 

You may also start an advanced similarity search for this article.