Sox9 expression in canine epithelial skin tumors

  • E. Fantinato | eleonora.fantinato@unimi.it University of Milan, Italy.
  • L. Milani University of Milan, Italy.
  • G. Sironi University of Milan, Italy.

Abstract

Sox9 is a master regulatory gene involved in developmental processes, stem cells maintenance and tumorigenesis. This gene is expressed in healthy skin but even in several skin neoplasms, where its expression patterns often resembles those of the developing hair follicle. In this study, samples from eleven different types of canine skin neoplasms (squamous papilloma, squamous cell carcinoma, infundibular keratinizing acanthoma, inferior tricholemmoma, isthmic tricholemmoma, trichoblastoma, trichoepitelioma, malignant trichoepitelioma, pilomatricoma, subungual keratoacanthoma, subungual squamous cell carcinoma) were immunohistochemically stained and evaluated for Sox9 with the aim to correlate tumor phenotype with molecular characteristics that may help to better define tumor development, contribute to its diagnosis and clinical management. Keratoacanthoma excluded, all the skin neoplasms examined showed a variable positivity to Sox9, especially in the basal layers, but with major intensity in neoplasms developing from the bulge region of the hair follicle, as trichoblastoma. According to our results, Sox9 could be employed as a stem cell marker to better assess the role of stem cells in canine epidermal and follicular tumors.

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Author Biographies

E. Fantinato, University of Milan

Department of Veterinary Science and Public Health

Veterinary University Hospital

Pathology Unit

Lodi

 

L. Milani, University of Milan

Department of Veterinary Science and Public Health

Veterinary University Hospital

Pathology Unit

Lodi

 
G. Sironi, University of Milan

Department of Veterinary Science and Public Health

Veterinary University Hospital

Pathology Unit

Lodi

 
Published
2015-07-09
Section
Brief Reports
Keywords:
Sox9, dog, epidermal tumors, hair follicle tumors, immunohistochemistry.
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How to Cite
Fantinato, E., Milani, L., & Sironi, G. (2015). Sox9 expression in canine epithelial skin tumors. European Journal of Histochemistry, 59(3). https://doi.org/10.4081/ejh.2015.2514