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Sox9 expression in canine epithelial skin tumors

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Sox9 is a master regulatory gene involved in developmental processes, stem cells maintenance and tumorigenesis. This gene is expressed in healthy skin but even in several skin neoplasms, where its expression patterns often resembles those of the developing hair follicle. In this study, samples from eleven different types of canine skin neoplasms (squamous papilloma, squamous cell carcinoma, infundibular keratinizing acanthoma, inferior tricholemmoma, isthmic tricholemmoma, trichoblastoma, trichoepitelioma, malignant trichoepitelioma, pilomatricoma, subungual keratoacanthoma, subungual squamous cell carcinoma) were immunohistochemically stained and evaluated for Sox9 with the aim to correlate tumor phenotype with molecular characteristics that may help to better define tumor development, contribute to its diagnosis and clinical management. Keratoacanthoma excluded, all the skin neoplasms examined showed a variable positivity to Sox9, especially in the basal layers, but with major intensity in neoplasms developing from the bulge region of the hair follicle, as trichoblastoma. According to our results, Sox9 could be employed as a stem cell marker to better assess the role of stem cells in canine epidermal and follicular tumors.

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Laura Bongiovanni, Chiara Brachelente, Eva Moreno, Monika M. Welle (2020)
Canine Epithelial Skin Tumours: Expression of the Stem Cell Markers Lgr5, Lgr6 and Sox9 in Light of New Cancer Stem Cell Theories. Veterinary Sciences, 7(2), 62.
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Sophie Nelissen, Andrew D. Miller (2024)
Assessment of SOX10 expression in 437 canine neoplasms of different embryologic origins. Veterinary Pathology, 61(5), 704.
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Wencke Reineking, Ida E. Schauerte, Johannes Junginger, Marion Hewicker-Trautwein (2022)
Sox9, Hopx, and survivin and tuft cell marker DCLK1 expression in normal canine intestine and in intestinal adenoma and adenocarcinoma. Veterinary Pathology, 59(3), 415.
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Dominique J. Wiener (2021)
Histologic features of hair follicle neoplasms and cysts in dogs and cats: a diagnostic guide. Journal of Veterinary Diagnostic Investigation, 33(3), 479.
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Mengchao Wang, Zhiheng Wang, Xiaosong Zhi, Wenbin Ding, Jun Xiong, Tian Tao, Yun Yang, Hongxia Zhang, Xiaoyuan Zi, Weiping Zhou, Gang Huang (2020)
SOX9 enhances sorafenib resistance through upregulating ABCG2 expression in hepatocellular carcinoma. Biomedicine & Pharmacotherapy, 129, 110315.
E. Fantinato, University of Milan

Department of Veterinary Science and Public Health

Veterinary University Hospital

Pathology Unit

Lodi

 

L. Milani, University of Milan

Department of Veterinary Science and Public Health

Veterinary University Hospital

Pathology Unit

Lodi

 
G. Sironi, University of Milan

Department of Veterinary Science and Public Health

Veterinary University Hospital

Pathology Unit

Lodi

 

How to Cite



Sox9 expression in canine epithelial skin tumors. (2015). European Journal of Histochemistry, 59(3). https://doi.org/10.4081/ejh.2015.2514