https://doi.org/10.4081/ejh.2015.2515

Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription

Vol. 59 No. 2 (2015)
Submitted: 3 March 2015
Accepted: 4 April 2015
Published: 21 April 2015
Ozone, in vitro culture, epithelial cells, cell nucleus, cytoskeleton, mitochondria, heat shock proteins
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Authors

M. Costanzo
University of Verona, Italy.
B. Cisterna
University of Verona, Italy.
A. Vella
University of Verona, Italy.
T. Cestari
University of Verona, Italy.
V. Covi
San Rocco Clinic, Italy.
G. Tabaracci
San Rocco Clinic, Italy.
M. Malatesta
manuela.malatesta@univr.it
University of Verona, Italy.

Ozone therapy is a modestly invasive procedure based on the regeneration capabilities of low ozone concentrations and used in medicine as an alternative/adjuvant treatment for different diseases. However, the cellular mechanisms accounting for the positive effects of mild ozonization are still largely unexplored. To this aim, in the present study the effects of low ozone concentrations (1 to 20 µg O3/mL O2) on structural and functional cell features have been investigated in vitro by using morphological, morphometrical, cytochemical and immunocytochemical techniques at bright field, fluorescence and transmission electron microscopy. Cells exposed to pure O2 or air served as controls. The results demonstrated that the effects of ozoneadministration are dependent on gas concentration, and the cytoskeletal organization, mitochondrial activity and nuclear transcription may be differently affected. This suggests that, to ensure effective and permanent metabolic cell activation, ozone treatments should take into account the cytological and cytokinetic features of the different tissues. 

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M. Costanzo, University of Verona
Department of Neurological and Movement Sciences, Anatomy and Histology Section
B. Cisterna, University of Verona
Department of Neurological and Movement Sciences, Anatomy and Histology Section
A. Vella, University of Verona
Department of Pathology and Diagnostics, Immunology Section
T. Cestari, University of Verona
Department of Pathology and Diagnostics, Immunology Section
M. Malatesta, University of Verona
Department of Neurological and Movement Sciences, Anatomy and Histology Section

How to Cite

Costanzo, M., Cisterna, B., Vella, A., Cestari, T., Covi, V., Tabaracci, G., & Malatesta, M. (2015). Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription. European Journal of Histochemistry, 59(2). https://doi.org/10.4081/ejh.2015.2515

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