https://doi.org/10.4081/ejh.2015.2571
Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis
Accepted: 12 November 2015
HTML: 754
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Extracellular signal-regulated kinases (ERK) 1, 2 and 3 are involved in cell proliferation and differentiation, and apoptosis; although ERK1/2 have been widely studied, limited knowledge on ERK3 is available. The present work aimed at investigating ERK3 distribution during cell cycle and apoptosis in human tumor HeLa cells. The analysis performed by double immunofluorescence and immunoelectron microscopy experiments revealed that during interphase ERK3 is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis, it remains in the nucleus in the form of massive nuclear aggregates, then moves to the cytoplasm and is finally extruded.
Supporting Agencies
University of PaviaHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Kazuhiko Hashimoto, Yutaka Oda, Fumihisa Nakamura, Ryosuke Kakinoki, Masao Akagi, Lectin-like, oxidized low-density lipoprotein receptor-1-deficient mice show resistance to age-related knee osteoarthritis , European Journal of Histochemistry: Vol. 61 No. 1 (2017)
- S. He, J. Yang, Maturation of neurotransmission in the developing rat cochlea: immunohistochemical evidence from differential expression of synaptophysin and synaptobrevin 2 , European Journal of Histochemistry: Vol. 55 No. 1 (2011)
- M. Riccio, E. Resca, T. Maraldi, A. Pisciotta, A. Ferrari, G. Bruzzesi, A. De Pol, Human dental pulp stem cells produce mineralized matrix in 2D and 3D cultures , European Journal of Histochemistry: Vol. 54 No. 4 (2010)
- Wenjing Liu, Shanshan Ming, Xiaobing Zhao, Xin Zhu, Yuxiang Gong, Developmental expression of high-mobility group box 1 (HMGB1) in the mouse cochlea , European Journal of Histochemistry: Vol. 67 No. 3 (2023)
- Hui Xu, Yanbo Chen, Qi Chen, Huan Xu, Yanxia Wang, Jiao Yu, Juan Zhou, Zhong Wang, Bing Xu, DNMT1 regulates IL-6- and TGF-β1-induced epithelial mesenchymal transition in prostate epithelial cells , European Journal of Histochemistry: Vol. 61 No. 2 (2017)
- P. Demurtas, M. Corrias, I. Zucca, C. Maxia, F. Piras, P. Sirigu, M.T. Perra, Angiotensin II: immunohistochemical study in Sardinian pterygium , European Journal of Histochemistry: Vol. 58 No. 3 (2014)
- Tadashi Yasui, Hiroshi Gomi, Taishi Kitahara, Azuma Tsukise, Ultrastructure and immunohistochemical characterization of proteins concerned with the secretory machinery in goat ceruminous glands , European Journal of Histochemistry: Vol. 61 No. 3 (2017)
- I. Ferrandino, R. Favorito, M. C. Grimaldi, Cadmium induces changes on ACTH and PRL cells in Podarcis sicula Lizard pituitary gland , European Journal of Histochemistry: Vol. 54 No. 4 (2010)
- W. Romero-Fernandez, D.O. Borroto-Escuela, V. Vargas-Barroso, M. Narváez, M. Di Palma, L.F. Agnati, J. Larriva Sahd, K. Fuxe, Dopamine D1 and D2 receptor immunoreactivities in the arcuate-median eminence complex and their link to the tubero-infundibular dopamine neurons , European Journal of Histochemistry: Vol. 58 No. 3 (2014)
- S. Battistelli, B. Citterio, B. Baldelli, C. Parlani, M. Malatesta, Histochemical and morphometrical study of mouse intestine epithelium after a long term diet containing genetically modified soybean , European Journal of Histochemistry: Vol. 54 No. 3 (2010)
<< < 22 23 24 25 26 27 28 29 30 31 > >>
You may also start an advanced similarity search for this article.
