https://doi.org/10.4081/ejh.2015.2571
Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis
Accepted: 12 November 2015
HTML: 754
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Extracellular signal-regulated kinases (ERK) 1, 2 and 3 are involved in cell proliferation and differentiation, and apoptosis; although ERK1/2 have been widely studied, limited knowledge on ERK3 is available. The present work aimed at investigating ERK3 distribution during cell cycle and apoptosis in human tumor HeLa cells. The analysis performed by double immunofluorescence and immunoelectron microscopy experiments revealed that during interphase ERK3 is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis, it remains in the nucleus in the form of massive nuclear aggregates, then moves to the cytoplasm and is finally extruded.
Supporting Agencies
University of PaviaHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- L Vecchio, B Cisterna, M Malatesta, TE Martin, M Biggiogera, Ultrastructural analysis of testes from mice fed on genetically modified soybean , European Journal of Histochemistry: Vol. 48 No. 4 (2004)
- F Di Meglio, D Nurzynska, C Castaldo, A Arcucci, L De Santo, M de Feo, M Cotrufo, S Montagnani, G Giordano-Lanza, In vitro cultured progenitors and precursors of cardiac cell lineages from human normal and post-ischemic hearts , European Journal of Histochemistry: Vol. 51 No. 4 (2007)
- M Wilcke, E Walum, Characterization of Leptin Intracellular Trafficking , European Journal of Histochemistry: Vol. 44 No. 4 (2000)
- G Tabellini, G Baldini, G Baldini, R Bortul, R Bareggi, P Narducci, AM Martelli, Localization of the small monomeric GTPases Rab3D and Rab3A in the AtT- 20 rat pituitary cell line , European Journal of Histochemistry: Vol. 45 No. 4 (2001)
- J. Melrose, The knee joint loose body as a source of viable autologous human chondrocytes , European Journal of Histochemistry: Vol. 60 No. 2 (2016)
- M Malatesta, B Baldelli, S Battistelli, C Tiberi, E Manuali, M Biggiogera, Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean , European Journal of Histochemistry: Vol. 49 No. 3 (2005)
- S. Nemolato, J. Ekstrom, T. Cabras, C. Gerosa, D. Fanni, E. Di Felice, A. Locci, I. Messana, M. Castagnola, G. Faa, Immunoreactivity for thymosin beta 4 and thymosin beta 10 in the adult rat oro-gastro-intestinal tract , European Journal of Histochemistry: Vol. 57 No. 2 (2013)
- JY Li, B Hu, XJ Wang, SL Wang, Temporal and spatial expression of TGF-b 2 in tooth crown development in mouse first lower molar , European Journal of Histochemistry: Vol. 52 No. 4 (2008)
- V. Rizzatti, F. Boschi, M. Pedrotti, E. Zoico, A. Sbarbati, M. Zamboni, Lipid droplets characterization in adipocyte differentiated 3T3-L1 cells: size and optical density distribution , European Journal of Histochemistry: Vol. 57 No. 3 (2013)
- Y. Shinohara, K. Okamoto, Y. Goh, N. Kiga, I. Tojyo, S. Fujita, Inhibition of fibrous adhesion formation in the temporomandibular joint of tenascin-C knockout mice , European Journal of Histochemistry: Vol. 58 No. 4 (2014)
<< < 43 44 45 46 47 48 49 50 51 52 > >>
You may also start an advanced similarity search for this article.
