https://doi.org/10.4081/ejh.2015.2571
Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis
Accepted: 12 November 2015
HTML: 754
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Extracellular signal-regulated kinases (ERK) 1, 2 and 3 are involved in cell proliferation and differentiation, and apoptosis; although ERK1/2 have been widely studied, limited knowledge on ERK3 is available. The present work aimed at investigating ERK3 distribution during cell cycle and apoptosis in human tumor HeLa cells. The analysis performed by double immunofluorescence and immunoelectron microscopy experiments revealed that during interphase ERK3 is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis, it remains in the nucleus in the form of massive nuclear aggregates, then moves to the cytoplasm and is finally extruded.
Supporting Agencies
University of PaviaHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- G Tabellini, G Baldini, G Baldini, R Bortul, R Bareggi, P Narducci, AM Martelli, Localization of the small monomeric GTPases Rab3D and Rab3A in the AtT- 20 rat pituitary cell line , European Journal of Histochemistry: Vol. 45 No. 4 (2001)
- M Malatesta, B Baldelli, S Battistelli, C Tiberi, E Manuali, M Biggiogera, Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean , European Journal of Histochemistry: Vol. 49 No. 3 (2005)
- J. Melrose, The knee joint loose body as a source of viable autologous human chondrocytes , European Journal of Histochemistry: Vol. 60 No. 2 (2016)
- B Helliot, B Panis, JP Busogoro, S Sobry, Y Poumay, M Raes, R Swennen, P Lepoivre, Immunogold silver staining associated with epi-fluorescence for cucumber mosaic virus localisation on semi-thin sections of banana tissues , European Journal of Histochemistry: Vol. 51 No. 2 (2007)
- YH Huang, M Jiang, BY Fu, Immunocytochemical localization of monoamine oxidase type B in rat liver , European Journal of Histochemistry: Vol. 52 No. 1 (2008)
- A. De Luca, C. Squillacioti, M.E. Pero, S. Paino, E. Langella, N. Mirabella, Urocortin-like immunoreactivity in the primary lymphoid organs of the duck (Anas platyrhynchos) , European Journal of Histochemistry: Vol. 53 No. 3 (2009)
- Sonia Fantone, Giovanni Tossetta, Rodolfo Montironi, Martina Senzacqua , Daniela Marzioni, Roberta Mazzucchelli, Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study , European Journal of Histochemistry: Vol. 64 No. 4 (2020)
- AI Scovassi, A Torriglia, Activation of DNA-degrading enzymes during apoptosis , European Journal of Histochemistry: Vol. 47 No. 3 (2003)
- A Sakar, S Vatansever, L Sepit, K Ozbilgin, A Yorgancioglu1, Effect of recombinant human activated protein C on apoptosis-related proteins , European Journal of Histochemistry: Vol. 51 No. 2 (2007)
- A Nanci, R Wazen, C Nishio, SF Zalzal, Immunocytochemistry of matrix proteins in calcified tissues: functional biochemistry on section , European Journal of Histochemistry: Vol. 52 No. 4 (2008)
<< < 44 45 46 47 48 49 50 51 52 53 > >>
You may also start an advanced similarity search for this article.
