https://doi.org/10.4081/ejh.2015.2571
Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis
Accepted: 12 November 2015
HTML: 754
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Extracellular signal-regulated kinases (ERK) 1, 2 and 3 are involved in cell proliferation and differentiation, and apoptosis; although ERK1/2 have been widely studied, limited knowledge on ERK3 is available. The present work aimed at investigating ERK3 distribution during cell cycle and apoptosis in human tumor HeLa cells. The analysis performed by double immunofluorescence and immunoelectron microscopy experiments revealed that during interphase ERK3 is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis, it remains in the nucleus in the form of massive nuclear aggregates, then moves to the cytoplasm and is finally extruded.
Supporting Agencies
University of PaviaHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- R Bugorsky, JC Perriard, G Vassalli, Genetic selection system allowing monitoring of myofibrillogenesis in living cardiomyocytes derived from mouse embryonic stem cells , European Journal of Histochemistry: Vol. 52 No. 1 (2008)
- G. Chene, N. Radosevic-Robin, A.S. Tardieu, A. Cayre, I. Raoelfils, P. Dechelotte, J. Dauplat, F. Penault Llorca, Morphological and immunohistochemical study of ovarian and tubal dysplasia associated with tamoxifen , European Journal of Histochemistry: Vol. 58 No. 2 (2014)
- Giamaica Conti, Dario Bertossi, Elena Dai Prè, Chiara Cavallini, Maria Teresa Scupoli, Giulia Ricciardi, Pierpaolo Parnigotto, Yves Saban, Andrea Sbarbati, Pierfrancesco Nocini, Regenerative potential of the Bichat fat pad determined by the quantification of multilineage differentiating stress enduring cells , European Journal of Histochemistry: Vol. 62 No. 4 (2018)
- Antonella Vetuschi, Simona Pompili, Gian Piero Di Marco, Federico Calvaruso, Enzo Iacomino, Lidia Angelosante, Claudio Festuccia, Alessandro Colapietro, Roberta Sferra, Can the AGE/RAGE/ERK signalling pathway and the epithelial-to-mesenchymal transition interact in the pathogenesis of chronic rhinosinusitis with nasal polyps? , European Journal of Histochemistry: Vol. 64 No. 1 (2020)
- Yuchen Yao, Wenqian Xie, Di Chen, Yingying Han, Zhengrong Yuan, Haolin Zhang, Qiang Weng, Seasonal expressions of VEGF and its receptors VEGFR1 and VEGFR2 in the prostate of the wild ground squirrels (Spermophilus dauricus) , European Journal of Histochemistry: Vol. 65 No. 2 (2021)
- B Vitolo, MR Lidonnici, C Montecucco, A Montecucco, A new monoclonal antibody against DNA ligase I is a suitable marker of cell proliferation in cultured cell and tissue section samples , European Journal of Histochemistry: Vol. 49 No. 4 (2005)
- N Sjakste, T Sjakste, Possible involvement of DNA strand breaks in regulation of cell differentiation , European Journal of Histochemistry: Vol. 51 No. 2 (2007)
- A Gigante, S Manzotti, C Bevilacqua, M Orciani, R Di Primio, M Mattioli-Belmonte, Adult mesenchymal stem cells for bone and cartilage engineering: effect of scaffold materials , European Journal of Histochemistry: Vol. 52 No. 3 (2008)
- C. Squillacioti, A. De Luca, S. Paino, E. Langella, N. Mirabella, Effects of castration on the expression of the NGF and TrkA in the vas deferens and accessory male genital glands of the rat , European Journal of Histochemistry: Vol. 53 No. 4 (2009)
- D. Kluchova, A. Bolekova, C. Heichel, A. J. Bron, I. Kozak, NADPH-diaphorase expression in the Meibomian glands of rat palpebra in postnatal development , European Journal of Histochemistry: Vol. 54 No. 4 (2010)
<< < 51 52 53 54 55 56 57 58 59 60 > >>
You may also start an advanced similarity search for this article.
