https://doi.org/10.4081/ejh.2015.2571
Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis
Accepted: 12 November 2015
HTML: 754
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Extracellular signal-regulated kinases (ERK) 1, 2 and 3 are involved in cell proliferation and differentiation, and apoptosis; although ERK1/2 have been widely studied, limited knowledge on ERK3 is available. The present work aimed at investigating ERK3 distribution during cell cycle and apoptosis in human tumor HeLa cells. The analysis performed by double immunofluorescence and immunoelectron microscopy experiments revealed that during interphase ERK3 is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis, it remains in the nucleus in the form of massive nuclear aggregates, then moves to the cytoplasm and is finally extruded.
Supporting Agencies
University of PaviaHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- Yan Yan Li, Ya Ping Feng, Li Liu, Jin Ke, Xing Long, Inhibition of HMGB1 suppresses inflammation and catabolism in temporomandibular joint osteoarthritis via NF-κB signaling pathway , European Journal of Histochemistry: Vol. 66 No. 3 (2022)
- S Burattini, P Ferri, M Battistelli, R Curci, F Luchetti, E Falcieri, C2C12 murine myoblasts as a model of skeletal muscle development: morpho-functional characterization , European Journal of Histochemistry: Vol. 48 No. 3 (2004)
- C Evangelisti, R Bortul, G Tabellini, V Papa, L Cocco, AM Martelli, Nuclear expression of diacylglycerol kinases: possible involvement in DNA replication , European Journal of Histochemistry: Vol. 50 No. 1 (2006)
- L. Casadei, L. Vallorani, A.M. Gioacchini, M. Guescini, S. Burattini, A. D'Emilio, L. Biagiotti, E. Falcieri, V. Stocchi, Proteomics-based investigation in C2C12 myoblast differentiation , European Journal of Histochemistry: Vol. 53 No. 4 (2009)
- J Wiejak, L Surmacz, E Wyroba, Effect of wortmannin and phorbol ester on Paramecium fluid-phase uptake in the presence of transferrin , European Journal of Histochemistry: Vol. 45 No. 4 (2001)
- S. Shibata, Y. Sakamoto, O. Baba, C. Qin, G. Murakami, B.H. Cho, An immunohistochemical study of matrix proteins in the craniofacial cartilage in midterm human fetuses , European Journal of Histochemistry: Vol. 57 No. 4 (2013)
- Manuela Malatesta, Histological and Histochemical Methods - Theory and practice , European Journal of Histochemistry: Vol. 60 No. 1 (2016)
- Andrea Ferrigno, Laura G. Di Pasqua, Clarissa Berardo, Veronica Siciliano, Plinio Richelmi, Mariapia Vairetti, Oxygen tension-independent protection against hypoxic cell killing in rat liver by low sodium , European Journal of Histochemistry: Vol. 61 No. 2 (2017)
- P Sirigu, F Piras, L Minerba, D Murtas, C Maxia, R Colombari, A Corbu, MT Perra, J Ugalde, Prognostic prediction of the immunohistochemical expression of p16 and p53 in cutaneous melanoma: a comparison of two populations from different geographical regions , European Journal of Histochemistry: Vol. 50 No. 3 (2006)
- Mengling Li, Yan Zhao, Jiayi Zhang, Wang Jiang, Siyuan Peng, Jinyue Hu, Yueming Shen, Deubiquitinase USP14 is upregulated in Crohn's disease and inhibits the NOD2 pathway mediated inflammatory response in vitro , European Journal of Histochemistry: Vol. 68 No. 3 (2024)
<< < 54 55 56 57 58 59 60 61 62 63 > >>
You may also start an advanced similarity search for this article.
