https://doi.org/10.4081/ejh.2015.2571
Analysis of ERK3 intracellular localization: dynamic distribution during mitosis and apoptosis
Accepted: 12 November 2015
HTML: 754
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Extracellular signal-regulated kinases (ERK) 1, 2 and 3 are involved in cell proliferation and differentiation, and apoptosis; although ERK1/2 have been widely studied, limited knowledge on ERK3 is available. The present work aimed at investigating ERK3 distribution during cell cycle and apoptosis in human tumor HeLa cells. The analysis performed by double immunofluorescence and immunoelectron microscopy experiments revealed that during interphase ERK3 is mainly resident in the nucleoplasm in association with ribonuclear proteins involved in early pre-mRNA splicing, it undergoes cell cycle-dependent redistribution and, during apoptosis, it remains in the nucleus in the form of massive nuclear aggregates, then moves to the cytoplasm and is finally extruded.
Supporting Agencies
University of PaviaHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- L. Pieri, C. Sassoli, P. Romagnoli, L. Domenici, Use of periodate-lysine-paraformaldehyde for the fixation of multiple antigens in human skin biopsies , European Journal of Histochemistry: Vol. 46 No. 4 (2002)
- N.P.E. Kadoglou, P. Moustardas, A. Kapelouzou, M. Katsimpoulas, A. Giagini, E. Dede, N. Kostomitsopoulos, P.E. Karayannacos, A. Kostakis, C.D. Liapis, The anti-inflammatory effects of exercise training promote atherosclerotic plaque stabilization in apolipoprotein E knockout mice with diabetic atherosclerosis , European Journal of Histochemistry: Vol. 57 No. 1 (2013)
- C. Loreto, C. Galanti, G. Musumeci, M. C. Rusu, R. Leonardi, Immunohistochemical analysis of matrix metalloproteinase-13 in human caries dentin , European Journal of Histochemistry: Vol. 58 No. 1 (2014)
- T. Al-dhohorah, M. Mashrah, Z. Yao, J. Huang, Aberrant DKK3 expression in the oral leukoplakia and oral submucous fibrosis: a comparative immunohistochemical study , European Journal of Histochemistry: Vol. 60 No. 2 (2016)
- Heiko Braak, Simone Feldengut, Jan Kassubek, Deniz Yilmazer-Hanke, Kelly Del Tredici, Two histological methods for recognition and study of cortical microinfarcts in thick sections , European Journal of Histochemistry: Vol. 62 No. 4 (2018)
- A Franchini, E Peruzzi, E Ottaviani, Morphochemical age-related changes in the nematode Caenorhabditis elegans: immunoperoxidase localization of cytokine- and growth factor-like molecules , European Journal of Histochemistry: Vol. 47 No. 1 (2003)
- M Biggiogera, L Cocco, FA Manzoli, Structure and function of the cell nucleus , European Journal of Histochemistry: Vol. 48 No. 1 (2004)
- Chaoyong Tian, Yang Yang, Yao Li, Fei Sun, Juan Qu, Dingjun Zha, Expression and localization of α2A-adrenergic receptor in the rat post-natal developing cochlea , European Journal of Histochemistry: Vol. 67 No. 3 (2023)
- M Battistelli, R De Sanctis, R De Bellis, L Cucchiarini, M Dachà , P Gobbi, Rhodiola Rosea as antioxidant in red blood cells: ultrastructural and hemolytic behaviour , European Journal of Histochemistry: Vol. 49 No. 3 (2005)
- E Brunelli, I Perrotta, A Bonacci, S Tripepi, Differential expression of aquaporin 3 in Triturus italicus from larval to adult epidermal conversion , European Journal of Histochemistry: Vol. 51 No. 1 (2007)
<< < 56 57 58 59 60 61 62 63 64 65 > >>
You may also start an advanced similarity search for this article.
