HLA-G expression and role in advanced-stage classical Hodgkin lymphoma

  • G. Caocci University of Cagliari, Italy.
  • M. Greco University of Cagliari, Italy.
  • D. Fanni | fandan73@yahoo.it University of Cagliari, Italy.
  • G. Senes University of Cagliari, Italy.
  • R. Littera University of Cagliari, Italy.
  • S. Lai University of Cagliari, Italy.
  • P. Risso University of Genoa, Italy.
  • C. Carcassi University of Cagliari, Italy.
  • G. Faa University of Cagliari, Italy.
  • G. La Nasa University of Cagliari, Italy.

Abstract

Non-classical human leucocyte antigen (HLA)-G class I molecules have an important role in tumor immune escape mechanisms. We investigated HLA-G expression in lymphonode biopsies taken from 8 controls and 20 patients with advanced-stage classical Hodgkin lymphoma (cHL), in relationship to clinical outcomes and the HLA-G 14-basepair (14-bp) deletion-insertion (del-ins) polymorphism. Lymphnode tissue sections were stained using a specific murine monoclonal HLA-G antibody. HLA-G protein expression was higher in cHL patients than controls. In the group of PET-2 positive (positron emission tomography carried out after 2 cycles of standard chemotherapy) patients with a 2-year progression-free survival rate (PFS) of 40%, we observed high HLA-G protein expression within the tumor microenvironment with low expression on Hodgkin and Reed-Sternberg (HRS) cells. Conversely, PET-2 negative patients with a PFS of 86% had higher HLA-G protein expression levels on HRS cells compared to the microenvironment. Lower expression on HRS cells was significantly associated with the HLA-G 14-bp ins/ins genotype. These preliminary data suggest that the immunohistochemical pattern of HLA-G protein expression may represent a useful tool for a tailored therapy in patients with cHL, based on the modulation of HLA-G expression in relation to achievement of negative PET-2.These preliminary data suggest that the immunohistochemical pattern of HLA-G protein expression may represent a useful tool for a tailored therapy in patients with cHL, based on the modulation of HLA-G expression in relation to achievement of negative PET-2.

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Published
2016-04-11
Section
Brief Reports
Keywords:
HLA-G, Hodgkin lymphoma, PET, NK cells, HRS cells.
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How to Cite
Caocci, G., Greco, M., Fanni, D., Senes, G., Littera, R., Lai, S., Risso, P., Carcassi, C., Faa, G., & La Nasa, G. (2016). HLA-G expression and role in advanced-stage classical Hodgkin lymphoma. European Journal of Histochemistry, 60(2). https://doi.org/10.4081/ejh.2016.2606

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