NO-tryptophan: a new small molecule located in the rat brain

DOI https://doi.org/10.4081/ejh.2016.2692

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Published: Sep 22, 2016
Original Papers

Issue
Vol 60, No 3 (2016)
Keywords
Lateral septal nucleus, septum, monoclonal antibody, cell body, nitric oxide, immunohistochemistry.
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How to Cite
Mangas, A., Yajeya, J., González, N., Duleu, S., Geffard, M., & Coveñas, R. (2016). NO-tryptophan: a new small molecule located in the rat brain. European Journal of Histochemistry, 60(3). https://doi.org/10.4081/ejh.2016.2692
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A. Mangas *
Gemacbio -Institute for the Development of Research in Human Pathology and Therapeutic (IDRPHT) - University of Salamanca, Spain.
J. Yajeya
University of Salamanaca, Department of Physiology, Spain.
N. González
Gemacbio, France.
S. Duleu
Institute for the Development of Research in Human Pathology and Therapeutic (IDRPHT), France.
M. Geffard
Gemacbio -Institute for the Development of Research in Human Pathology and Therapeutic (IDRPHT), France.
R. Coveñas
University of Salamanca, Institute of Neurosciences of Castilla y León (INCYL), Laboratory 14, Spain.
(*) Corresponding Author:
A. Mangas | amangas@gemacbio.com

Abstract

A highly specific monoclonal antibody directed against nitric oxide-tryptophan (NO-W) with good affinity (10-9 M) and specificity was developed. In the rat brain, using an indirect immunoperoxidase technique, cell bodies containing NO-W were exclusively found in the intermediate and dorsal parts of the lateral septal nucleus. No immunoreactive fibres were found in the rat brain. This work reports the first visualization and the morphological characteristics of cell bodies containing NO-W in the mammalian brain. The restricted distribution of NO-W in the rat brain suggests that this molecule could be involved in specific physiological mechanisms. 

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