https://doi.org/10.4081/ejh.2016.2692
NO-tryptophan: a new small molecule located in the rat brain
Submitted: 30 May 2016
Accepted: 24 August 2016
Published: 22 September 2016
Accepted: 24 August 2016
Abstract Views: 1182
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
A highly specific monoclonal antibody directed against nitric oxide-tryptophan (NO-W) with good affinity (10-9 M) and specificity was developed. In the rat brain, using an indirect immunoperoxidase technique, cell bodies containing NO-W were exclusively found in the intermediate and dorsal parts of the lateral septal nucleus. No immunoreactive fibres were found in the rat brain. This work reports the first visualization and the morphological characteristics of cell bodies containing NO-W in the mammalian brain. The restricted distribution of NO-W in the rat brain suggests that this molecule could be involved in specific physiological mechanisms.
Supporting Agencies
European Union FP7 Collaborative Grant TargetBraIn, GEMAC S.A. Laboratories, IDRPHTHow to Cite
Mangas, A., Yajeya, J., González, N., Duleu, S., Geffard, M., & Coveñas, R. (2016). NO-tryptophan: a new small molecule located in the rat brain. European Journal of Histochemistry, 60(3). https://doi.org/10.4081/ejh.2016.2692
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