Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kölliker’s organ in vivo in early stage after birth in rats

  • Jun Liu Shanghai Jiaotong University School of Medicine, China.
  • Linbin Cai Shanghai Jiaotong University School of Medicine, China.
  • Yuanyuan He Shanghai Jiaotong University School of Medicine, China.
  • Jun Yang | otology-xinhua@hotmail.com Shanghai Jiaotong University School of Medicine, China.

Abstract

Kölliker’s organ is a temporary but indispensable structure in the development of the cochlea. Supporting cells (SCs) within it release adenosine 5'-triphosphate (ATP), which may play a crucial role in cochlear development before the onset of hearing. To reveal the apoptosis of Kölliker’s  organ in new-born rats, we studied the morphological changes and expression of apoptosis-related factors during early postnatal development. We found SCs in Kölliker’s s organ decreased in number and changed in appearance along the cochlea apex-to-base gradient, and the expression of caspase-3, caspase-8, caspase-9 and bcl-2 in Kölliker’s  organ of the cochlea fluctuated along the course of postnatal development, with an expression peak at postnatal day 3. This study demonstrates a time-dependent degeneration of Kölliker’s  organ during postnatal cochlea development, which might be triggered by endogenous factors.Â

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Published
2017-08-07
Section
Original Papers
Supporting Agencies
National Natural Science Foundation of China, Shanghai Municipal Science and Technology Commission, Huawei Li, Fudan University.
Keywords:
Kölliker’s organ, supporting cells, apoptosis, development.
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How to Cite
Liu, J., Cai, L., He, Y., & Yang, J. (2017). Apoptosis pattern and alterations of expression of apoptosis-related factors of supporting cells in Kölliker’s organ in vivo in early stage after birth in rats. European Journal of Histochemistry, 61(3). https://doi.org/10.4081/ejh.2017.2706