https://doi.org/10.4081/ejh.2016.2724
High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling
Submitted: 13 September 2016
Accepted: 9 November 2016
Published: 21 November 2016
Accepted: 9 November 2016
Abstract Views: 1124
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
High temperature requirement A1 (HtrA1) is a secreted protease involved in placental development. Fibronectin (FN) is involved in important process such as wound healing, cell adhesion and spreading, growth, migration, and differentiation. The purpose of this study was to analyse the expression patterns of HtrA1 in relationship to FN and to the key growth zones of placenta such as mesenchymal villi as well as cell islands and cell columns. We demonstrated that FN and HtrA1 are localized in the placental key growth zones suggesting a pivotal role in maintaining the balance among the molecules involved in the placental development and differentiation.
Supporting Agencies
Italian Ministry and Research and Instruction, grant PRIN 2010-2011,How to Cite
Tossetta, G., Avellini, C., Licini, C., Giannubilo, S., Castellucci, M., & Marzioni, D. (2016). High temperature requirement A1 and fibronectin: two possible players in placental tissue remodelling. European Journal of Histochemistry, 60(4). https://doi.org/10.4081/ejh.2016.2724
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