OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas

  • Cristina Pirrone | cristina.pirrone@hotmail.it University of Insubria, Department of Clinical and Experimental Medicine, Italy.
  • Anna M. Chiaravalli Ospedale di Circolo, Department of Pathology, Italy.
  • Alessandro Marando University of Insubria, Department of Surgical and Morphological Science, Italy.
  • Andrea Conti University of Insubria, Department of Clinical and Experimental Medicine, Italy.
  • Alessia Rainero University of Insubria, Department of Clinical and Experimental Medicine, Italy.
  • Andrea Pistochini University of Insubria, Department of Biotechnology and Life Science, Italy.
  • Francesco Lo Curto University of Insubria, Department of Clinical and Experimental Medicine, Italy.
  • Francesco Pasquali University of Insubria, Department of Clinical and Experimental Medicine, Italy.
  • Paolo Castelnuovo University of Insubria, Department of Biotechnology and Life Science, Italy.
  • Carlo Capella University of Insubria, Department of Surgical and Morphological Science, Italy.
  • Giovanni Porta University of Insubria, Department of Clinical and Experimental Medicine, Italy.

Abstract

OTX Homeobox genes are involved in embryonic morphogenesis and in the development of olfactory epithelium in adult. Mutations occurring in the OTX genes are reported to be associated to tumorigenisis in human. No reports correlate the expression of OTX genes and neoplasms of the nasal cavity. Thus, through immunohistochemical and Real-time PCR analysis we investigated OTX1 and OTX2 expression in the more frequent types of nasal and sinonasal tumours. Variable expression of both genes were found in normal sinonasal mucosa and in tumours. Interestingly, no expression of both OTX genes were detected in sinonasal intestinal-type adenocarcinomas; only OTX1 was found in non-intestinal-type adenocarcinomas and OTX2 was selectively expressed in olfactory neuroblastomas. In conclusion, OTX1 and OTX2 genes might have a role in the pathogenesis of different types of sinonasal neoplasms.

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Published
2017-02-09
Section
Brief Reports
Supporting Agencies
Centro Grandi Strumenti University of Insubria Varese, Fondazione Comunitaria del Varesotto, Fondazione del Monte di Lombardia, Fondazione Anna Villa e Felice Rusconi
Keywords:
Homeobox genes, sinonasal neoplasms, immunohistochemistry, Real-time PCR, tumour marker.
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How to Cite
Pirrone, C., Chiaravalli, A. M., Marando, A., Conti, A., Rainero, A., Pistochini, A., Lo Curto, F., Pasquali, F., Castelnuovo, P., Capella, C., & Porta, G. (2017). OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas. European Journal of Histochemistry, 61(1). https://doi.org/10.4081/ejh.2017.2730