https://doi.org/10.4081/ejh.2017.2730
OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas
Accepted: 13 December 2016
HTML: 339
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
OTX Homeobox genes are involved in embryonic morphogenesis and in the development of olfactory epithelium in adult. Mutations occurring in the OTX genes are reported to be associated to tumorigenisis in human. No reports correlate the expression of OTX genes and neoplasms of the nasal cavity. Thus, through immunohistochemical and Real-time PCR analysis we investigated OTX1 and OTX2 expression in the more frequent types of nasal and sinonasal tumours. Variable expression of both genes were found in normal sinonasal mucosa and in tumours. Interestingly, no expression of both OTX genes were detected in sinonasal intestinal-type adenocarcinomas; only OTX1 was found in non-intestinal-type adenocarcinomas and OTX2 was selectively expressed in olfactory neuroblastomas. In conclusion, OTX1 and OTX2 genes might have a role in the pathogenesis of different types of sinonasal neoplasms.
Supporting Agencies
Centro Grandi Strumenti University of Insubria Varese, Fondazione Comunitaria del Varesotto, Fondazione del Monte di Lombardia, Fondazione Anna Villa e Felice RusconiHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- E. Akat, H. Arıkan, B. Göçmen, Histochemical and biometric study of the gastrointestinal system of Hyla orientalis (Bedriaga, 1890) (Anura, Hylidae) , European Journal of Histochemistry: Vol. 58 No. 4 (2014)
- Mohammed Akeel, Ahmed Elhafey , Atef Shehata , Erwa Elmakki , Thanaa Aboshouk, Hussein Ageely , Mohammed Salih Mahfouz , Efficacy of immunohistochemical staining in detecting Helicobacter pylori in Saudi patients with minimal and atypical infection , European Journal of Histochemistry: Vol. 65 No. 3 (2021)
- A. De Luca, C. Squillacioti, M.E. Pero, S. Paino, E. Langella, N. Mirabella, Urocortin-like immunoreactivity in the primary lymphoid organs of the duck (Anas platyrhynchos) , European Journal of Histochemistry: Vol. 53 No. 3 (2009)
- M.G. Bottone, G. Santin, C. Soldani, P. Veneroni, A.I. Scovassi, C. Alpini, Intracellular distribution of Tankyrases as detected by multicolor immunofluorescence techniques , European Journal of Histochemistry: Vol. 56 No. 1 (2012)
- M Zhou, HJ He, R Suzuki, O Tanaka, M Sekiguchi, Y Yasuoka, K Kawahara, H Itoh, H Abe, Expression of ATP sensitive K+ channel subunit Kir6.1 in rat kidney , European Journal of Histochemistry: Vol. 51 No. 1 (2007)
- Carolina dos Santos Jacob, Gabriela Klein Barbosa, Mariana Pasquini Rodrigues, Jurandyr Pimentel Neto, Lara Caetano Rocha, Adriano Polican Ciena, Stretching prior to resistance training promotes adaptations on the postsynaptic region in different myofiber types , European Journal of Histochemistry: Vol. 66 No. 1 (2022)
- R Cardani, E Mancinelli, G Rotondo, V Sansone, G Meola, Muscleblind-like protein 1 nuclear sequestration is a molecular pathology marker of DM1 and DM2 , European Journal of Histochemistry: Vol. 50 No. 3 (2006)
- Carlo Alberto Redi, Human embryonic stem cells handbook , European Journal of Histochemistry: Vol. 57 No. 1 (2013)
- G. Lepore, S. Gadau, A. Mura, M. Zedda, V. Farina, Aromatase immunoreactivity in fetal ovine neuronal cell cultures exposed to oxidative injury , European Journal of Histochemistry: Vol. 53 No. 4 (2009)
- A. Amaroli, M.G. Chessa, Detection and characterisation of NAD(P)H-diaphorase activity in Dictyostelium discoideum cells (Protozoa) , European Journal of Histochemistry: Vol. 56 No. 4 (2012)
<< < 51 52 53 54 55 56 57 58 59 60 > >>
You may also start an advanced similarity search for this article.
Publication Facts
Reviewer profiles N/A
Author statements
- Editor & editorial board
- profiles
- Academic society
- N/A
- Publisher
- PAGEPress Publications, Pavia, Italy
To learn about these publication facts, click 
PF is maintained by the Public Knowledge Project
