https://doi.org/10.4081/ejh.2017.2730
OTX1 and OTX2 as possible molecular markers of sinonasal carcinomas and olfactory neuroblastomas
Accepted: 13 December 2016
HTML: 340
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
OTX Homeobox genes are involved in embryonic morphogenesis and in the development of olfactory epithelium in adult. Mutations occurring in the OTX genes are reported to be associated to tumorigenisis in human. No reports correlate the expression of OTX genes and neoplasms of the nasal cavity. Thus, through immunohistochemical and Real-time PCR analysis we investigated OTX1 and OTX2 expression in the more frequent types of nasal and sinonasal tumours. Variable expression of both genes were found in normal sinonasal mucosa and in tumours. Interestingly, no expression of both OTX genes were detected in sinonasal intestinal-type adenocarcinomas; only OTX1 was found in non-intestinal-type adenocarcinomas and OTX2 was selectively expressed in olfactory neuroblastomas. In conclusion, OTX1 and OTX2 genes might have a role in the pathogenesis of different types of sinonasal neoplasms.
Downloads
Publication Facts
Reviewer profiles N/A
Author statements
- Editor & editorial board
- profiles
- Academic society
- N/A
- Publisher
- PAGEPress Publications, Pavia, Italy
To learn about these publication facts, click 
PF is maintained by the Public Knowledge Project
Citations
Supporting Agencies
Centro Grandi Strumenti University of Insubria Varese, Fondazione Comunitaria del Varesotto, Fondazione del Monte di Lombardia, Fondazione Anna Villa e Felice RusconiHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- N. Kiga, I. Tojyo, T. Matsumoto, Y. Hiraishi, Y. Shinohara, S. Makino, S. Fujita, Expression of lumican and fibromodulin following interleukin-1 beta stimulation of disc cells of the human temporomandibular joint , European Journal of Histochemistry: Vol. 55 No. 2 (2011)
- I. Kopera, M. Durlej, A. Hejmej, K. Knapczyk-Stwora, M. Duda, M. Slomczynska, M. Koziorowski, B. Bilinska, Effects of pre- and postnatal exposure to flutamide on connexin 43 expression in testes and ovaries of prepubertal pigs , European Journal of Histochemistry: Vol. 54 No. 2 (2010)
- Mariailaria Verderame, Ermelinda Limatola, Rosaria Scudiero, Metallothionein expression and synthesis in the testis of the lizard Podarcis sicula under natural conditions and following estrogenic exposure , European Journal of Histochemistry: Vol. 61 No. 2 (2017)
- Qingjing Gao, Wenqian Xie, Wenjing Lu, Yuning Liu, Haolin Zhang, Yingying Han, Qiang Weng, Seasonal patterns of prolactin, prolactin receptor, and STAT5 expression in the ovaries of wild ground squirrels (Citellus dauricus Brandt) , European Journal of Histochemistry: Vol. 67 No. 4 (2023)
- Lan Wang, Zhenyu Fan, Haijin Wang, Shougui Xiang, Propofol alleviates M1 polarization and neuroinflammation of microglia in a subarachnoid hemorrhage model in vitro, by targeting the miR-140-5p/TREM-1/NF-κB signaling axis , European Journal of Histochemistry: Vol. 68 No. 3 (2024)
- Kazuhiko Hashimoto, Yutaka Oda, Koichi Nakagawa, Terumasa Ikeda, Kazuhiro Ohtani, Masao Akagi, LOX-1 deficient mice show resistance to zymosan-induced arthritis , European Journal of Histochemistry: Vol. 62 No. 1 (2018)
- Rong Tian, Gengsheng Mao, Ghrelin reduces cerebral ischemic injury in rats by reducing M1 microglia/macrophages , European Journal of Histochemistry: Vol. 66 No. 1 (2022)
- T. Bujas, Z. Marusic, M. Peric Balja, A. Mijic, B. Kruslin, D. Tomas, MAGE-A3/4 and NY-ESO-1 antigens expression in metastatic esophageal squamous cell carcinoma , European Journal of Histochemistry: Vol. 55 No. 1 (2011)
- E. Wyroba, P. Kwaśniak, K. Miller, K. Kobyłecki, M. Osińska, Site-directed mutagenesis, in vivo electroporation and mass spectrometry in search for determinants of the subcellular targeting of Rab7b paralogue in the model eukaryote Paramecium octaurelia , European Journal of Histochemistry: Vol. 60 No. 2 (2016)
- Kazuhiko Hashimoto, Shunji Nishimura, Tomohiko Ito, Naohiro Oka, Ryosuke Kakinoki, Masao Akagi, Clinicopathological assessment of cancer/testis antigens NY‑ESO‑1 and MAGE‑A4 in osteosarcoma , European Journal of Histochemistry: Vol. 66 No. 3 (2022)
<< < 4 5 6 7 8 9 10 11 12 13 > >>
You may also start an advanced similarity search for this article.
