Bone morphogenetic protein-4 and bone morphogenetic protein receptors expressions in the adult rat eye

Submitted: 29 March 2017
Accepted: 23 June 2017
Published: 6 September 2017
Abstract Views: 1009
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We investigated the expressions of bone morphogenetic protein-4 (BMP4) and its receptors, bone morphogenetic protein receptor IA (BMPRIA), bone morphogenetic protein receptor IB (BMPRIB) and bone morphogenetic protein receptor II (BMPRII) in the adult rat eye. Interesting differences in expression profile were observed between BMPRIA and BMPRIB in the retina. BMPRIA-like immunoreactivity (IR) was very intensely seen in the photoreceptor layer, while BMPRIB-IR was mainly observed in the other layers. In the cornea, BMP4, BMPRIA, BMPRIB and BMPRII-IRs were abundantly seen in the cell body of basal cells in the corneal epithelium, and endothelium. In the lens, BMP4, BMPRIA, BMPRIB and BMPRII-IRs were observed in epithelial cells, lens cortical fiber cells, however they were not seen in the capsule and the central region of the lens. In the iris and ciliary body, strong BMP4 and BMPRIB-IRs were observed in nonpigmented epithelium. These results suggest that different kinds of BMP signaling should be needed in different areas in the adult eye to keep the shapes, differentiation levels, and functions of various cells.

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Supporting Agencies

Scientific Research Fund of the Ministry of Education, Science, and Cultures, Japan
Yuka Maruyama-Koide, Hamamatsu University School of Medicine
Department of Ophthalmology, Department of Organ and Tissue Anatomy
Sumiko Mikawa, Hamamatsu University School of Medicine
Department of Organ and Tissue Anatomy
Takeshi Sasaki, Hamamatsu University School of Medicine
Department of Organ and Tissue Anatomy
Kohji Sato, Hamamatsu University School of Medicine
Department of Organ and Tissue Anatomy

How to Cite

Maruyama-Koide, Y., Mikawa, S., Sasaki, T., & Sato, K. (2017). Bone morphogenetic protein-4 and bone morphogenetic protein receptors expressions in the adult rat eye. European Journal of Histochemistry, 61(3). https://doi.org/10.4081/ejh.2017.2797