https://doi.org/10.4081/ejh.2017.2851
DNA damage in acute myeloid leukemia patients of Northern Mexico
Submitted: 14 September 2017
Accepted: 30 November 2017
Published: 11 December 2017
Accepted: 30 November 2017
Abstract Views: 1030
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Publisher's note
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.
Supporting Agencies
Instituto Mexicano del Seguro Social, CONACYT.How to Cite
Dávila-Rodríguez, M. I., Cortés-Gutiérrez, E. I., Hernández-Valdés, R., Guzmán-Cortés, K., De León-Cantú, R. E., Cerda-Flores, R. M., & Báez-De la Fuente, E. (2017). DNA damage in acute myeloid leukemia patients of Northern Mexico. European Journal of Histochemistry, 61(4). https://doi.org/10.4081/ejh.2017.2851
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