https://doi.org/10.4081/ejh.2017.2851
DNA damage in acute myeloid leukemia patients of Northern Mexico
Accepted: 30 November 2017
HTML: 129
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
The purpose of this study was to evaluate DNA damage in the whole genome of peripheral blood leukocytes from patients with acute myeloid leukemia (AML) compared with a control group using DNA breakage detection-fluorescent in situ hybridization (DBD-FISH). Our results suggest that the DNA damage detected in patients with newly diagnosed AML was similar to that observed for the controls; this might be explained by the stimulation of a repair pathway by the pathogenesis itself. These findings indicate that inhibiting the repair pathway could be proposed to enhance the efficacy of chemotherapy.
Supporting Agencies
Instituto Mexicano del Seguro Social, CONACYT.How to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- A. Cataldi, S. Zara, M. Rapino, M. Zingariello, V. di Giacomo, A. Antonucci, p53 and telomerase control rat myocardial tissue response to hypoxia and ageing , European Journal of Histochemistry: Vol. 53 No. 4 (2009)
- Wei Wang, Wenbo Tang, Erbo Shan, Lei Zhang, Shiyuan Chen, Chaowen Yu, Yong Gao, MiR-130a-5p contributed to the progression of endothelial cell injury by regulating FAS , European Journal of Histochemistry: Vol. 66 No. 2 (2022)
- P. Narducci, R. Bortul, R. Bareggi, V. Nicolin, Clathrin-dependent endocytosis of membrane-bound RANKL in differentiated osteoclasts , European Journal of Histochemistry: Vol. 54 No. 1 (2010)
- CJ Woodall, DI Graham, Evidence for neuronal localisation of enteroviral sequences in motor neurone disease/amyotrophic lateral sclerosis by in situ hybridization , European Journal of Histochemistry: Vol. 48 No. 2 (2004)
- CarloAlberto Redi, Cytoskeleton - Methods and Protocols , European Journal of Histochemistry: Vol. 54 No. 1 (2010)
- C Shi, G Zhou, Y Zhu, Y Su, T Cheng, HE Zhau, LWK Chung, Quantum dots-based multiplexed immunohistochemistry of protein expression in human prostate cancer cells , European Journal of Histochemistry: Vol. 52 No. 2 (2008)
- M. Monti, In vivo cellular imaging using fluorescent proteins - Methods and Protocols , European Journal of Histochemistry: Vol. 56 No. 4 (2012)
- Tadashi Yasui, Kenya Miyata, Chie Nakatsuka, Azuma Tsukise, Hiroshi Gomi, Morphological and histochemical characterization of the secretory epithelium in the canine lacrimal gland , European Journal of Histochemistry: Vol. 65 No. 4 (2021)
- Carlo Alberto Redi, Cell cycle checkpoints: methods and protocols , European Journal of Histochemistry: Vol. 56 No. 3 (2012)
- S. Battistelli, B. Citterio, B. Baldelli, C. Parlani, M. Malatesta, Histochemical and morphometrical study of mouse intestine epithelium after a long term diet containing genetically modified soybean , European Journal of Histochemistry: Vol. 54 No. 3 (2010)
<< < 32 33 34 35 36 37 38 39 40 41 > >>
You may also start an advanced similarity search for this article.
