GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location

  • Mário S. de Souza Albuquerque Universidade Federal de Pernambuco, Brazil.
  • Antônio F. da Silva-filho Universidade Federal de Pernambuco, Brazil.
  • Marina Ferraz Cordeiro Universidade Federal de Pernambuco, Brazil.
  • Maria de Fátima Deodato de Souza Universidade Federal de Pernambuco, Brazil.
  • Michael W.L. Quirino Universidade Federal de Pernambuco, Brazil.
  • Luiza R. Amorim Lima Universidade Federal de Pernambuco, Brazil.
  • Maira G. da Rocha Pitta Universidade Federal de Pernambuco, Brazil.
  • Mario R. Martins Hospital do Câncer de Pernambuco, Brazil.
  • Moacyr J.B. de Melo Rêgo | moacyr.rego@gmail.com Universidade Federal de Pernambuco, Brazil.

Abstract

Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer.

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Published
2018-06-14
Section
Brief Reports
Supporting Agencies
CNPq, CAPES and FACEPE
Keywords:
Gastric adenocarcinoma, polypeptide N-acetylgalactosaminyltransferases, clinical-pathological analyses, immunohistochemistry.
Statistics
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How to Cite
de Souza Albuquerque, M. S., da Silva-filho, A. F., Ferraz Cordeiro, M., Deodato de Souza, M. de F., Quirino, M. W., Amorim Lima, L. R., da Rocha Pitta, M. G., Martins, M. R., & de Melo Rêgo, M. J. (2018). GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location. European Journal of Histochemistry, 62(2). https://doi.org/10.4081/ejh.2018.2931