GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location
- Mário S. de Souza Albuquerque Universidade Federal de Pernambuco, Brazil.
- Antônio F. da Silva-filho Universidade Federal de Pernambuco, Brazil.
- Marina Ferraz Cordeiro Universidade Federal de Pernambuco, Brazil.
- Maria de Fátima Deodato de Souza Universidade Federal de Pernambuco, Brazil.
- Michael W.L. Quirino Universidade Federal de Pernambuco, Brazil.
- Luiza R. Amorim Lima Universidade Federal de Pernambuco, Brazil.
- Maira G. da Rocha Pitta Universidade Federal de Pernambuco, Brazil.
- Mario R. Martins Hospital do Câncer de Pernambuco, Brazil.
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Moacyr J.B. de Melo Rêgo
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moacyr.rego@gmail.com
Universidade Federal de Pernambuco, Brazil.
Abstract
Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer.
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Copyright (c) 2018 Mário S. de Souza Albuquerque, Antônio F. da Silva-filho, Marina Ferraz Cordeiro, Maria de Fátima Deodato de Souza, Michael W.L. Quirino, Luiza R. Amorim Lima, Maira G. da Rocha Pitta, Mario R. Martins, Moacyr J.B. de Melo Rêgo
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
