https://doi.org/10.4081/ejh.2018.2931
GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location
Submitted: 23 March 2018
Accepted: 4 June 2018
Published: 14 June 2018
Accepted: 4 June 2018
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Supplementary: 186
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Supplementary: 186
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All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer.
Supporting Agencies
CNPq, CAPES and FACEPEHow to Cite
de Souza Albuquerque, M. S., da Silva-filho, A. F., Ferraz Cordeiro, M., Deodato de Souza, M. de F., Quirino, M. W., Amorim Lima, L. R., … de Melo Rêgo, M. J. (2018). GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location. European Journal of Histochemistry, 62(2). https://doi.org/10.4081/ejh.2018.2931
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