https://doi.org/10.4081/ejh.2018.2931

GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location

Vol. 62 No. 2 (2018)
Submitted: 23 March 2018
Accepted: 4 June 2018
Published: 14 June 2018
Gastric adenocarcinoma, polypeptide N-acetylgalactosaminyltransferases, clinical-pathological analyses, immunohistochemistry.
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Authors

Mário S. de Souza Albuquerque
Universidade Federal de Pernambuco, Brazil.
Antônio F. da Silva-filho
Universidade Federal de Pernambuco, Brazil.
Marina Ferraz Cordeiro
Universidade Federal de Pernambuco, Brazil.
Maria de Fátima Deodato de Souza
Universidade Federal de Pernambuco, Brazil.
Michael W.L. Quirino
Universidade Federal de Pernambuco, Brazil.
Luiza R. Amorim Lima
Universidade Federal de Pernambuco, Brazil.
Maira G. da Rocha Pitta
Universidade Federal de Pernambuco, Brazil.
Mario R. Martins
Hospital do Câncer de Pernambuco, Brazil.
Moacyr J.B. de Melo Rêgo
moacyr.rego@gmail.com
Universidade Federal de Pernambuco, Brazil.

Gastric cancer (GC) is the second most common cause of cancer-related deaths in the world. This study aims to investigate the differential tissue expression of ppGalNAc-T15 and to evaluate its possible association with clinical-pathological parameters and outcome of gastric adenocarcinoma patients. For these 70 patients were evaluated the expression by immunohistochemistry to ppGalNAc-T15. Our results showed that 33 (47.1%) patients were ppGalNAC-T15+ positive and 37 (52.9%) negative. Positive staining for ppGalNAc-T15 was significantly present in patients older than 60 years (P=0.0306) and submitted to total gastrectomy (P=0.0087). Also, some results remained at the limit of significance as surgical standing (P=0.0562) and histological grade (P=0.0549). Therefore, the ppGalNAc-T15 immunoreactivity can be useful to understand the prognosis of patients with gastric cancer.

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Supporting Agencies

CNPq, CAPES and FACEPE

How to Cite

de Souza Albuquerque, M. S., da Silva-filho, A. F., Ferraz Cordeiro, M., Deodato de Souza, M. de F., Quirino, M. W., Amorim Lima, L. R., … de Melo Rêgo, M. J. (2018). GalNAc-T15 in gastric adenocarcinoma: Characterization according to tissue architecture and cellular location. European Journal of Histochemistry, 62(2). https://doi.org/10.4081/ejh.2018.2931

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