Low ozone concentrations promote adipogenesis in human adipose-derived adult stem cells
- Manuela Costanzo University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Italy.
- Federico Boschi University of Verona, Department of Computer Science, Italy.
- Flavia Carton Department of Neurosciences, Biomedicine and Movement Sciences, Italy.
- Giamaica Conti Department of Neurosciences, Biomedicine and Movement Sciences, Italy.
- Viviana Covi San Rocco Clinic, Italy.
- Gabriele Tabaracci San Rocco Clinic, Italy.
- Andrea Sbarbati Department of Neurosciences, Biomedicine and Movement Sciences, Italy.
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Manuela Malatesta
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manuela.malatesta@univr.it
University of Verona, Department of Neurosciences, Biomedicine and Movement Sciences, Italy.
http://orcid.org/0000-0001-8196-9232
Abstract
Ozone is a strong oxidant, highly unstable atmospheric gas. Its medical use at low concentrations has been progressively increasing as an alternative/adjuvant treatment for several diseases. In this study, we investigated the effects of mild ozonisation on human adipose-derived adult stem (hADAS) cells i.e., mesenchymal stem cells occurring in the stromal-vascular fraction of the fat tissue and involved in the tissue regeneration processes. hADAS cells were induced to differentiate into the adipoblastic lineage, and the effect of low ozone concentrations on the adipogenic process was studied by combining histochemical, morphometric and ultrastructural analyses. Our results demonstrate that ozone treatment promotes lipid accumulation in hADAS without inducing deleterious effects, thus paving the way to future studies aimed at elucidating the effect of mild ozonisation on adipose tissue for tissue regeneration and engineering.
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Copyright (c) 2018 Manuela Costanzo, Federico Boschi, Flavia Carton, Giamaica Conti, Viviana Covi, Gabriele Tabaracci, Andrea Sbarbati, Manuela Malatesta
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
