Epidermal growth factor-like domain multiple 7 (EGFL7): Expression and possible effect on biliary epithelium growth in cholangiocarcinoma

  • Caterina L. Mammola Sapienza University of Rome, Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Italy. https://orcid.org/0000-0001-9221-3932
  • Antonella Vetuschi University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, Italy. https://orcid.org/0000-0002-0237-3834
  • Luigi Pannarale Sapienza University of Rome, Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Italy.
  • Roberta Sferra University of L'Aquila, Department of Biotechnological and Applied Clinical Sciences, Italy.
  • Romina Mancinelli | romina.mancinelli@uniroma1.it Sapienza University of Rome, Department of Anatomical, Histological, Forensic Medicine and Orthopedics Sciences, Italy. http://orcid.org/0000-0003-2040-0581

Abstract

Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with limited treatment options and low survival rates. The intrahepatic subtype comprises two forms: mucin-iCCA and mixed-iCCA. Epidermal growth factor-like domain multiple (EGFL7) is overexpressed in less differentiated liver tumors. The aim of this study was to assess the presence of EGFL7 due to its possible role in the growth of CCA. Hematoxylin and Eosin and periodic acid-Schiff staining were used to evaluate the morphological aspects and glycogen deposition. Immunohistochemistry and immunofluorescence were performed to identify the presence of EGFL7 both in tumor sections ex vivo and in appropriate cell lines in culture. We found that EGFL7 is expressed in malignant cholangiocytes of mixed-iCCA and absent in mucin-iCCA. In conclusion the expression of EGFL7 might be useful in the classification of CCA subtypes.

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Published
2018-11-30
Section
Brief Reports
Supporting Agencies
This project received financial support from “Progetti piccoli di Ateneo 2017” of Sapienza University of Rome
Keywords:
Liver, biliary epithelium, cholangiocytes, cholangiocarcinoma, EGFL7
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How to Cite
Mammola, C. L., Vetuschi, A., Pannarale, L., Sferra, R., & Mancinelli, R. (2018). Epidermal growth factor-like domain multiple 7 (EGFL7): Expression and possible effect on biliary epithelium growth in cholangiocarcinoma. European Journal of Histochemistry, 62(4). https://doi.org/10.4081/ejh.2018.2971

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