https://doi.org/10.4081/ejh.2018.2971
Epidermal growth factor-like domain multiple 7 (EGFL7): Expression and possible effect on biliary epithelium growth in cholangiocarcinoma
Accepted: 14 November 2018
Supplementary: 0
HTML: 12
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Cholangiocarcinoma (CCA) is an aggressive biliary tract malignancy with limited treatment options and low survival rates. The intrahepatic subtype comprises two forms: mucin-iCCA and mixed-iCCA. Epidermal growth factor-like domain multiple (EGFL7) is overexpressed in less differentiated liver tumors. The aim of this study was to assess the presence of EGFL7 due to its possible role in the growth of CCA. Hematoxylin and Eosin and periodic acid-Schiff staining were used to evaluate the morphological aspects and glycogen deposition. Immunohistochemistry and immunofluorescence were performed to identify the presence of EGFL7 both in tumor sections ex vivo and in appropriate cell lines in culture. We found that EGFL7 is expressed in malignant cholangiocytes of mixed-iCCA and absent in mucin-iCCA. In conclusion the expression of EGFL7 might be useful in the classification of CCA subtypes.
Supporting Agencies
This project received financial support from “Progetti piccoli di Ateneo 2017” of Sapienza University of RomeHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- D. Fanni, N. Iacovidou, A. Locci, C. Gerosa, S. Nemolato, P. Van Eyken, G. Monga, S. Mellou, G. Faa, V. Fanos, MUC1 marks collecting tubules, renal vesicles, comma- and S-shaped bodies in human developing kidney , European Journal of Histochemistry: Vol. 56 No. 4 (2012)
- M. Salemi, A. Galia, F. Fraggetta, C. La Corte, P. Pepe, S. La Vignera, G. Improta, P. Bosco, A.E. Calogero, Poly (ADP-ribose) polymerase 1 protein expression in normal and neoplastic prostatic tissue , European Journal of Histochemistry: Vol. 57 No. 2 (2013)
- J. Zhang, J. Luo, J. Ni, L. Tang, H.P. Zhang, L. Zhang, J.F. Xu, D. Zheng, MMP-7 is upregulated by COX-2 and promotes proliferation and invasion of lung adenocarcinoma cells , European Journal of Histochemistry: Vol. 58 No. 1 (2014)
- Sonia Fantone, Giovanni Tossetta, Rodolfo Montironi, Martina Senzacqua , Daniela Marzioni, Roberta Mazzucchelli, Ciliary neurotrophic factor (CNTF) and its receptor (CNTFRα) signal through MAPK/ERK pathway in human prostate tissues: a morphological and biomolecular study , European Journal of Histochemistry: Vol. 64 No. 4 (2020)
- Michael W.L. Quirino, Amanda P.B. Albuquerque, Maria F.D. de Souza, Antônio F. da Silva Filho, Mário R. Martins, Maira G. da Rocha Pitta, Michelly C. Pereira, Moacyr J.B. de Melo Rêgo, alpha2,3 sialic acid processing enzymes expression in gastric cancer tissues reveals that ST3Gal3 but not Neu3 are associated with Lauren's classification, angiolymphatic invasion and histological grade , European Journal of Histochemistry: Vol. 66 No. 4 (2022)
- M Malatesta, B Baldelli, S Battistelli, C Tiberi, E Manuali, M Biggiogera, Reversibility of hepatocyte nuclear modifications in mice fed on genetically modified soybean , European Journal of Histochemistry: Vol. 49 No. 3 (2005)
- S. Soddu, E. Di Felice, S. Cabras, M.E. Castellanos, L. Atzori, G. Faa, L. Pilloni, IMP-3 expression in keratoacanthomas and squamous cell carcinomas of the skin: an immunohistochemical study , European Journal of Histochemistry: Vol. 57 No. 1 (2013)
- M. Costanzo, B. Cisterna, A. Vella, T. Cestari, V. Covi, G. Tabaracci, M. Malatesta, Low ozone concentrations stimulate cytoskeletal organization, mitochondrial activity and nuclear transcription , European Journal of Histochemistry: Vol. 59 No. 2 (2015)
- AM Mazzone, M Aita, F Gabrielli, E Moriconi, D De Orsi, Identification of cells secreting a thymostimulin-like substance and examination of some histoenzymatic pathways in aging avian primary lymphatic organs: II. Bursa of Fabricius , European Journal of Histochemistry: Vol. 47 No. 4 (2003)
- Hui Xu, Yanbo Chen, Qi Chen, Huan Xu, Yanxia Wang, Jiao Yu, Juan Zhou, Zhong Wang, Bing Xu, DNMT1 regulates IL-6- and TGF-β1-induced epithelial mesenchymal transition in prostate epithelial cells , European Journal of Histochemistry: Vol. 61 No. 2 (2017)
<< < 19 20 21 22 23 24 25 26 27 28 > >>
You may also start an advanced similarity search for this article.
