https://doi.org/10.4081/ejh.2019.2981
Deleted in Liver Cancer 2 (DLC2) protein expression in hepatocellular carcinoma
Accepted: 8 February 2019
HTML: 17
All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article or claim that may be made by its manufacturer is not guaranteed or endorsed by the publisher.
Authors
Deleted in Liver Cancer (DLC) proteins belong to the family of RhoGAPs and are believed to operate as negative regulators of the Rho family of small GTPases. So far, the role of the first identified member from the DLC family, DLC1, was established as a tumor suppressor in hepatocellular carcinoma. The function of its close family relative, DLC2 is unequivocal. In the present study we attempted to determine whether the loss of DLC2 is a common feature of hepatocellular carcinoma tissue. We examined two types of hepatocellular carcinoma- typical and fibrolamellar one. Our analysis revealed that DLC2 protein is not diminished in cancer tissue when compared to non-cancerous liver specimens. What is more, we observed DLC2 to be more abundantly expressed in cancer tissue, particularly in tumors with the inflammation background. In addition, we found that DLC2 gene status was diploid in virtually all tumor samples examined. Our results indicate that DLC2 is not diminished in hepatocellular carcinoma cells. It appears that members of the DLC family, although structurally highly related, may function differently in cancer cells.
Supporting Agencies
Polish State Committee for Scientific Research, Medical University of Warsaw, PolandHow to Cite
PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.
Similar Articles
- A. Porzionato, G. Fenu, M. Rucinski, V. Macchi, A. Montella, L. K. Malendowicz, R. De Caro, KISS1 and KISS1R expression in the human and rat carotid body and superior cervical ganglion , European Journal of Histochemistry: Vol. 55 No. 2 (2011)
- Feng Chen, Wenfeng Li, Dandan Zhang, Youlin Fu, Wenjin Yuan, Gang Luo, Fuwei Liu, Jun Luo, MALAT1 regulates hypertrophy of cardiomyocytes by modulating the miR-181a/HMGB2 pathway , European Journal of Histochemistry: Vol. 66 No. 3 (2022)
- Lu Liu, Zhankui Liu, Liu Yang, Xue Wu, Jiaying Zhu, Lili Liu, Yang Liu, Lobetyolin suppressed lung cancer in a mouse model by inhibiting epithelial-mesenchymal transition , European Journal of Histochemistry: Vol. 66 No. 3 (2022)
- S. Nemolato, P. Van Eyken, T. Cabras, F. Cau, M.U. Fanari, A. Locci, D. Fanni, C.L.P. Gerosa, I. Messana, M. Castagnola, G. Faa, Expression pattern of thymosin beta 4 in the adult human liver , European Journal of Histochemistry: Vol. 55 No. 3 (2011)
- T. Nara, T. Yasui, O. Fujimori, W. Meyer, A. Tsukise, Histochemical properties of sialic acids and antimicrobial substances in canine anal glands , European Journal of Histochemistry: Vol. 55 No. 3 (2011)
- S. Strobel, J.A. Encarnação, N.I. Becker, T.E. Trenczek, Histological and histochemical analysis of the gastrointestinal tract of the common pipistrelle bat (Pipistrellus pipistrellus) , European Journal of Histochemistry: Vol. 59 No. 2 (2015)
- Xuanjin Zhu, Weilu Jia, Yong Yan, Yong Huang, Bailin Wang, NOP14 regulates the growth, migration, and invasion of colorectal cancer cells by modulating the NRIP1/GSK-3β/β-catenin signaling pathway , European Journal of Histochemistry: Vol. 65 No. 3 (2021)
You may also start an advanced similarity search for this article.
