VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas

Submitted: 6 January 2019
Accepted: 18 February 2019
Published: 5 March 2019
Abstract Views: 1042
PDF: 625
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Authors

Vascular endothelial growth factor (VEGF), its inhibitory splice variant, VEGF165b and Endocrine Gland derived VEGF (EG-VEGF) have a controversial role in pituitary gland. We aim to study VEGF, VEGF165b and EG-VEGF expression in pituitary adenomas. A significant correlation was found between growth hormone (GH) and VEGF secretion (P=0.024). For prolactinomas, VEGF and prolactin expression, had a P-value of 0.02 for Kendall coefficient and a P-value of 0.043 for the Spearman coefficient. VEGF-mRNA amplification was detected in both tumor cells and folliculostellate cells. VEGF165b was positive in 16.66% of pituitary adenomas. EG-VEGF was significantly correlated with prolactin (P=0.025) and luteinizing hormone (P=0.028). Our data strongly support VEGF, VEGF165b and EG-VEGF as important players of pituitary adenomas tumorigenesis. Particular hormonal milieu heterogeneity, special vascular network with an unusual reactivity to tumor growth correlated with variability of VEGF, VEGF165b and EG-VEGF secretion may stratify pituitary adenomas in several molecular groups with a direct impact on therapy and prognosis.

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Supporting Agencies

The present work was supported by the “Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania

How to Cite

Corlan, A. S., Cîmpean, A. M., Melnic, E., Raica, M., & Sarb, S. (2019). VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas. European Journal of Histochemistry, 63(1). https://doi.org/10.4081/ejh.2019.3010

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