VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas

  • Ana Silvia Corlan Victor Babeș University of Medicine and Pharmacy, Department of Microscopic Morphology/Histology, Romania.
  • Anca Maria Cîmpean | ancacimpean1972@yahoo.com Victor Babeș University of Medicine and Pharmacy, Department of Microscopic Morphology/Histology; Angiogenesis Research Center, Romania.
  • Eugen Melnic Nicolae Testemiţanu State University of Medicine and Pharmacy, Department of Pathology, Moldova, Republic of.
  • Marius Raica Victor Babeș University of Medicine and Pharmacy, Department of Microscopic Morphology/Histology; Angiogenesis Research Center, Romania.
  • Simona Sarb Victor Babeș University of Medicine and Pharmacy, Department of Microscopic Morphology/Histology, Romania.

Abstract

Vascular endothelial growth factor (VEGF), its inhibitory splice variant, VEGF165b and Endocrine Gland derived VEGF (EG-VEGF) have a controversial role in pituitary gland. We aim to study VEGF, VEGF165b and EG-VEGF expression in pituitary adenomas. A significant correlation was found between growth hormone (GH) and VEGF secretion (P=0.024). For prolactinomas, VEGF and prolactin expression, had a P-value of 0.02 for Kendall coefficient and a P-value of 0.043 for the Spearman coefficient. VEGF-mRNA amplification was detected in both tumor cells and folliculostellate cells. VEGF165b was positive in 16.66% of pituitary adenomas. EG-VEGF was significantly correlated with prolactin (P=0.025) and luteinizing hormone (P=0.028). Our data strongly support VEGF, VEGF165b and EG-VEGF as important players of pituitary adenomas tumorigenesis. Particular hormonal milieu heterogeneity, special vascular network with an unusual reactivity to tumor growth correlated with variability of VEGF, VEGF165b and EG-VEGF secretion may stratify pituitary adenomas in several molecular groups with a direct impact on therapy and prognosis.

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Published
2019-03-05
Section
Original Papers
Supporting Agencies
The present work was supported by the “Victor Babeș” University of Medicine and Pharmacy, Timișoara, Romania
Keywords:
VEGF, VEGF165b, EG-VEGF, pituitary adenomas, angiogenesis
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How to Cite
Corlan, A. S., Cîmpean, A. M., Melnic, E., Raica, M., & Sarb, S. (2019). VEGF, VEGF165b and EG-VEGF expression is specifically related with hormone profile in pituitary adenomas. European Journal of Histochemistry, 63(1). https://doi.org/10.4081/ejh.2019.3010