https://doi.org/10.4081/ejh.2020.3113

MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction

Vol. 64 No. 2 (2020)
Submitted: 23 January 2020
Accepted: 27 March 2020
Published: 16 April 2020
MMP-7, MMP-9, TMJ synovial, TMJ dysfunction
Abstract Views: 915
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Authors

Carla Loreto
https://orcid.org/0000-0001-6301-9743
Department of Biomedical and Biotechnological Sciences, Section of Anatomy, University of Catania, Italy.
Vera Filetti
verofiletti@gmail.com
https://orcid.org/0000-0001-9668-5048
Department of Biomedical and Biotechnological Sciences, Section of Anatomy, University of Catania, Italy.
Luis Eduardo Almeida
https://orcid.org/0000-0002-9802-3782
School of Dentistry, Marquette University, Milwaukee, WI, United States.
Giusy Rita Maria La Rosa
https://orcid.org/0000-0001-5127-5299
Department of Orthodontics, School of Dentistry, University of Catania, Italy.
Rosalia Leonardi
Department of Orthodontics, School of Dentistry, University of Catania, Italy.
Cristina Grippaudo
https://orcid.org/0000-0002-9499-0556
Department of Orthodontics, School of Dentistry, Catholic University of the Sacred Heart, Rome, Italy.
Antonino Lo Giudice
https://orcid.org/0000-0001-6086-2348
Department of Orthodontics, School of Dentistry, University of Catania, Italy.

Matrix metalloproteinases (MMPs) are tissue-enzymes that play a key role during the remodeling process, such as in inflammatory diseases. MMP-7 and MMP-9 have been shown to be implicated in extracellular matrix homeostasis and in joint disc remodeling. The objective of this study was to determine the relation of MMP-7 and MMP-9 expression with severe temporomandibular joint dysfunction, in particular with anterior disk displacement without reduction (ADDwoR), using an immunohistochemical approach. Therefore, twenty human temporomandibular synovia in the test group and ten in the control group were collected. The results showed there was a statistically significant difference (P<0.001) for morphometric and densitometric analysis of both detected MMPs in control and test groups. In conclusion, MMP-7 and MMP-9 were overexpressed in the synovial tissue of patients with ADDwoR.

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How to Cite

Loreto, C., Filetti, V., Almeida, L. E., La Rosa, G. R. M., Leonardi , R., Grippaudo , C., & Lo Giudice, A. (2020). MMP-7 and MMP-9 are overexpressed in the synovial tissue from severe temporomandibular joint dysfunction . European Journal of Histochemistry, 64(2). https://doi.org/10.4081/ejh.2020.3113

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