Prognostic significance of CD133 and ABCB5 expression in papillary thyroid carcinoma

https://doi.org/10.4081/ejh.2020.3143

Authors

  • Maria Augusta Karas Zella | mjzella@outlook.com Medical Research Institute, Mackenzie Evangelical School of Medicine, Curitiba, Brazil. https://orcid.org/0000-0001-5768-4456
  • Ana Paula Martins Sebastião Department of Pathology, Nossa Senhora das Graças Hospital, Curitiba, Brazil. https://orcid.org/0000-0002-2993-577X
  • Luiz Martins Collaço Department of Pathology, Mackenzie Evangelical School of Medicine, Curitiba, Brazil. https://orcid.org/0000-0002-3215-1650
  • Daniel Cury Ogata Department of Pathology, Universidade do Vale do Itajai, Santa Catarina, Brazil. https://orcid.org/0000-0001-8819-2155
  • Guilherme Cecchetti Mackenzie Evangelical School of Medicine, Curitiba, Brazil. https://orcid.org/0000-0002-0256-6353
  • Ivan José Paredes Bartolomei Mackenzie Evangelical School of Medicine, Curitiba, Brazil. https://orcid.org/0000-0002-0609-4381
  • Ana Maria Waaga-Gasser Renal Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, United States.
  • Carmen Australia Paredes Marcondes Ribas Mackenzie Evangelical School of Medicine, Curitiba, Brazil.

Abstract

Expression of CD133 and ABCB5 is associated with tumor aggressiveness, but evidence in papillary thyroid cancer (PTC) is lacking. We correlated CD133 and ABCB5 expression with pathological characteristics and factors of worse prognosis in PTC. Samples of 119 PTCs and 40 controls (goiters) were distributed in 8 tissue microarray blocks and evaluated with immunohistochemistry using anti-CD133 and anti-ABCB5 antibodies. The expression of each marker alone and combined was analyzed against pathological characteristics and factors of worse prognosis in PTC. Expression of CD133 alone (19 tumors, 16.0%) was more frequent in patients with versus without lymph node metastases (P=0.024). Expression of ABCB5 alone (n=95, 83.3%) was associated with larger tumor size (P=0.045). CD133-ABCB5 coexpression was not associated with pathological characteristics or factors of worse prognosis in PTC.

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Published
2020-11-12
Info
Issue
Section
Brief Reports
Supporting Agencies
Mackenzie Evangelical College of Paraná (Curitiba, Paraná, Brazil), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brasil (CAPES)
Keywords:
CD133 protein, human, prominin 1 protein, human, ATP-binding cassette transporter, subfamily B, ABCB5 protein, human, immunohistochemistry, cancer, papillary thyroid
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How to Cite
Karas Zella, M. A., Sebastião, A. P. M. ., Collaço, L. M. ., Ogata, D. C. ., Cecchetti, G. ., Bartolomei, I. J. P. ., Waaga-Gasser, A. M. ., & Ribas, C. A. P. M. . (2020). Prognostic significance of CD133 and ABCB5 expression in papillary thyroid carcinoma. European Journal of Histochemistry, 64(4). https://doi.org/10.4081/ejh.2020.3143

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